Studies on the Mechanism of the Toxic Action of Organic Halogen Compounds

Hirade, Junkichirô; Ninomiya, A.

doi:10.1093/oxfordjournals.jbchem.a126178

Cited by 37 publications

(19 citation statements)

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“…8 While the partially oxidized sulfoxide is considered nontoxic, the sulfone has vesicant properties similar to the parent HD. 8d, 9 Therefore, selective partial oxidation is critical for the safe degradation of HD. 8 When using strong oxidizing agents, such as hydrogen peroxide and tert-butyl hydroperoxide, both partially and fully oxidized products are often observed.…”

Section: Introductionmentioning

confidence: 99%

Efficient and selective oxidation of sulfur mustard using singlet oxygen generated by a pyrene-based metal–organic framework

et al. 2016

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A pyrene-based metal-organic framework (MOF) NU-1000 was used as a heterogeneous photocatalyst for the degradation of a sulfur mustard simulant, 2-chloroethyl ethyl sulfide (CEES). Using irradiation from a commercially available and inexpensive ultraviolet (UV) light-emitting diode (LED), singlet oxygen (1O2) is generated by NU-1000 and selectively oxidizes CEES to the nontoxic product 2-chloroethyl ethyl sulfoxide (CEESO). More importantly, this method was tested on the warfare agent sulfur mustard (HD) for the first time using 1O2 and a MOF catalyst, and this method proved to be effective in oxidizing sulfur mustard to nontoxic products without forming the toxic sulfone by-product.

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Section: Introductionmentioning

confidence: 99%

Efficient and selective oxidation of sulfur mustard using singlet oxygen generated by a pyrene-based metal–organic framework

et al. 2016

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“…[9] The dehydrohalogenation pathway also tendst ob et oo slow for most practical applications. [11] The first known materials applied for the oxidative detoxification of sulfur mustard were bleaching powders of varying strength and composition. [11] The first known materials applied for the oxidative detoxification of sulfur mustard were bleaching powders of varying strength and composition.…”

Section: Introductionmentioning

confidence: 99%

Postsynthetic Incorporation of a Singlet Oxygen Photosensitizer in a Metal–Organic Framework for Fast and Selective Oxidative Detoxification of Sulfur Mustard

Howarth

Buru

Liu

et al. 2016

Chemistry A European J

105

102

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A fullerene-based photosensitizer is incorporated postsynthetically into a Zr -based MOF, NU-1000, for enhanced singlet oxygen production. The structural organic linkers in the MOF platform also act as photosensitizers which contribute to the overall generation of singlet oxygen from the material under UV irradiation. The singlet oxygen generated by the MOF/fullerene material is shown to oxidize sulfur mustard selectively to the less toxic bis(2-chloroethyl)sulfoxide with a half-life of only 11 min.

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“…In Nb(V)‐layered saponite materials, niobium sites are able to trigger the selective oxidation of organic sulfides into sulfoxides, prevent their over‐oxidation into sulfones (the sulfones derived from blister agents are indeed as toxic as the pristine chemical weapon) and hence transform highly hazardous agents into products with far reduced toxicity. However, no studies have been performed so far, to our best knowledge, about the effects of the physico‐chemical features of the Nb‐containing catalysts onto the catalytic behavior.…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical Properties, Biological and Environmental Impact of Nb-saponites Catalysts for the Oxidative Degradation of Chemical Warfare Agents

et al. 2017

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Niobium‐containing saponite clays are active catalysts, under mild ambient conditions and in the presence of aqueous hydrogen peroxide, in the oxidative abatement of sulfur‐containing blister chemical warfare agent simulants, such as (2‐chloroethyl)ethyl sulfide. Over a Nb‐saponite solid, a complete, selective and safe abatement of the chemical agent was attained within 8 h. The biological and environmental impact of the Nb‐containing nanostructured clays used as decontamination solids was assessed by specific rapid biotoxicity tests on bioluminescent bacteria and vegetable plants. No negative impact on the strain of luminescent bacteria was evidenced in terms of acute and chronic toxicity. No adverse effects have been observed on vegetable plants in terms of germination, vigour and induction of chlorophyll fluorescence either.

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Studies on the Mechanism of the Toxic Action of Organic Halogen Compounds

Cited by 37 publications

References 0 publications

Efficient and selective oxidation of sulfur mustard using singlet oxygen generated by a pyrene-based metal–organic framework

Efficient and selective oxidation of sulfur mustard using singlet oxygen generated by a pyrene-based metal–organic framework

Postsynthetic Incorporation of a Singlet Oxygen Photosensitizer in a Metal–Organic Framework for Fast and Selective Oxidative Detoxification of Sulfur Mustard

Physico-chemical Properties, Biological and Environmental Impact of Nb-saponites Catalysts for the Oxidative Degradation of Chemical Warfare Agents

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