1982
DOI: 10.1172/jci110487
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Studies on the Mechanism of Sodium Excretion during Drug-induced Vasodilatation in the Dog

Abstract: A B S T R A C T The administration of vasodilating agents such as bradykinin and acetylcholine cause an increase in urinary sodium excretion. Yet the mechanisms involved in this natriuretic effect are not clear. Recent studies with another renal vasodilator, secretin have shown this drug also causes a profound increase in renal blood flow but without major changes in sodium excretion. To attempt to delineate the basis of this difference in sodium excretion with these drugs, the renal functional effects of secr… Show more

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Cited by 57 publications
(24 citation statements)
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“…9 The present study demonstrated that the ANF induced natriuresis is not dependent on a redistribution of RBF to the juxtamedullary cortex.…”
Section: Discussionsupporting
confidence: 55%
See 1 more Smart Citation
“…9 The present study demonstrated that the ANF induced natriuresis is not dependent on a redistribution of RBF to the juxtamedullary cortex.…”
Section: Discussionsupporting
confidence: 55%
“…Others have shown that acetylcholine, a vasodilator, produces a natriuretic effect accompanied by an increase in medullary blood flow 9 - 18 and that secretin, a vasodilator, fails to produce natriuresis or increase medullary blood flow. 9 The present study demonstrated that the ANF induced natriuresis is not dependent on a redistribution of RBF to the juxtamedullary cortex.…”
Section: Discussionmentioning
confidence: 99%
“…8 The important role of PPF in the regulation of sodium excretion is further supported by a recent study demonstrating that increased PPF is associated with increased sodium excretion after administration of acetylcholine and bradykinin. 7 Our present study, however, failed to demonstrate any association between increased sodium excretion and alteration of medullary blood flow after acute elevation of renal perfusion pressure. The PPF was unchanged despite a significant rise in MAP.…”
contrasting
confidence: 98%
“…Recently, several studies have demonstrated a significant role of papillary plasma flow 7 and papillary tissue tonicity*- 9 in the regulation of sodium excretion. The blood flow to the inner medulla of the kidney is poorly autoregulated, according to some investigators.…”
mentioning
confidence: 99%
“…Clearance studies have shown that infusion of kinins into the renal artery produces natriuresis and diuresis (1)(2)(3)(4). Micropuncture and tissue-tonicity studies have further suggested that bradykinin-induced redistribution of blood flow toward the medulla and the resulting medullary washout could, at least in part, account for these effects (5,6). On the other hand, recent enzymatic and anatomic data suggest an action of the kallikrein-kinin system within the cortex.…”
Section: Introductionmentioning
confidence: 99%