Studies on the Local Factors in Dental Caries. I. Destruction of Plaques and Retardation of Bacterial Growth in the Oral Cavity

Hanke, Milton T.

doi:10.14219/jada.archive.1940.0269

Cited by 43 publications

(15 citation statements)

References 2 publications

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“…Hanke, 25 Sweet et al, 26 and Rams et al 7 comment that CHT significantly reduces bacterial colonization, especially in peri-implantitis and in post-extraction bacteremia. In the present study, CHT was found to have the same microbial growth reduction as that provided by CHX and was effective when compared with the control group (Figure).…”

Section: Discussionmentioning

confidence: 99%

Antiseptics and microcosm biofilm formation on titanium surfaces

et al. 2016

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Oral rehabilitation with osseointegrated implants is a way to restore esthetics and masticatory function in edentulous patients, but bacterial colonization around the implants may lead to mucositis or peri-implantitis and consequent implant loss. Peri-implantitis is the main complication of oral rehabilitation with dental implants and, therefore, it is necessary to take into account the potential effects of antiseptics such as chlorhexidine (CHX), chloramine T (CHT), triclosan (TRI), and essential oils (EO) on bacterial adhesion and on biofilm formation. To assess the action of these substances, we used the microcosm technique, in which the oral environment and periodontal conditions are simulated in vitro on titanium discs with different surface treatments (smooth surface -SS, acid-etched smooth surface -AESS, sand-blasted surface -SBS, and sand-blasted and acid-etched surface -SBAES). Roughness measurements yielded the following results: SS: 0.47 µm, AESS: 0.43 µm, SB: 0.79 µm, and SBAES: 0.72 µm. There was statistical difference only between SBS and AESS. There was no statistical difference among antiseptic treatments. However, EO and CHT showed lower bacterial counts compared with the saline solution treatment (control group). Thus, the current gold standard (CHX) did not outperform CHT and EO, which were efficient in reducing the biofilm biomass compared with saline solution.

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Section: Discussionmentioning

confidence: 99%

Antiseptics and microcosm biofilm formation on titanium surfaces

et al. 2016

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“…Zinc salts have an antiplaque effect first observed by Hanke [1940] and more recently demonstrated in humans by Skjorland et al [1978] and by Harrap et al [1983]. They also reduce the acidogenicity of plaque [Oppermann et al, 1980], Saxton et al [1986] have demonstrated that plaque growth is reduced during periods of habitual toothbrushing with dentifrices that contain zinc citrate.…”

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confidence: 96%

Long-Term Exposure of Plaque to Zinc Citrate

et al. 1988

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The effect of 3 years’ continuous exposure to dentifrices containing different levels of sodium monofluorophosphate, with or without 0.5% zinc citrate, has been investigated on plaque growth inhibition. Additionally, changes in the plaque microflora during prolonged exposure to zinc have been monitored in children with high or low caries increments. Following long-term use the inhibitory effect of zinc citrate on plaque growth was fully maintained. There was no evidence that prolonged exposure to zinc caused shifts in the plaque population of Streptococcus mutans, Streptococcus sanguis, lactobacilli, or Actinomyces species. A positive association was observed between children with high caries increments and high numbers of S. mutans in plaque and saliva. Caries increments were also associated with total viable count per microgram plaque protein. A negative association was observed between combined caries increment and number of S. sanguis in plaque.

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“…Previous studies have reported the use of topically applied zinc salts for the con trol of plaque and/or calculus deposits in vivo [Addy et al, 1980;Fischman et al, 1973;Hanke, 1940;Picozzi et al, 1972;Schmid et al, 1974], Sources of zinc used in these and subsequent preparations have included zinc chloride [Lobene et al, 1985;Schmid et al, 1974], zinc citrate [PretaraSpanedda et al, 1985;Addy et al, 1980], combinations of zinc citrate and zinc tribromsalan [Fischman et al, 1973] and combinations of zinc chloride and sanguinarine [Southard et al, 1985]. Cur rently, a number of commercial dentifrice products are being marketed which con tain zinc citrate or zinc chloride for plaque and/or calculus control.1…”

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confidence: 99%