Studies on the Intracellular Distribution of Boron Modified Tetracycline Analogs TA in Tumor Cells A Preliminary Report

Abstract

The tetracycline analogs (TA) have been modified to contain boron. The new family of compounds provides a tool to reevaluate the over 40-year-old theory of thermal neutron, capture therapy for malignant cells.This report presents some tissue culture observations of the boron (TA) treated cells concerning intracellular incorporation and distribution. The synthesis of the boron TAs will be presented at a later date.

The Chemistry of Neutron Capture Therapy

“…The planar tetracyclic nucleus in the tetracyclines has the capacity for intercalation, and this was the basis in part for the synthesis of dihydroxyboryl analogues of the tetracyclines. − One of the compounds that was synthesized was evaluated both in tumor cell culture and in adenocarcinoma-bearing mice. The preliminary results indicated some potential, suggesting possible binding to ribosomes.…”