Studies on the interaction of extended terpyridyl and triazine metal complexes with DNA

A Cytostatic Ruthenium(II)–Platinum(II) Bis(terpyridyl) Anticancer Complex That Blocks Entry into S Phase by Up‐regulating p27KIP1

“…In contrast to ethidium bromide, neither complex VR52 nor VR54 increased the relative viscosity of DNA solutions (Figure 1 c), indicating that these complexes are not metallo‐intercalators. This behaviour is consistent with previous reports on other extended Ru II –terpyridyl complexes 29…”

A [4+2] mixed ligand approach to ruthenium DNA metallointercalators [Ru(tpa)(N–N)](PF6)2 using a tris(2-pyridylmethyl)amine (tpa) capping ligand

“…On the other hand, the K B of 1 was too small to be determined by this method and can only be estimated to be <10 3 M À1 . These results compare well with binding constants determined for other Ru metallointercalators [29,[35][36][37].…”

A Multifunctional Biomimicking Oxidovanadium(V) Complex: Synthesis, DFT Calculations, Bromo‐peroxidation and DNA Nuclease Activities

“…No significant change in viscosity is observed as compared to EB‐DNA system (EB is a classical DNA intercalator; hence the viscosity of DNA solutions increases with increasing concentration of EB). This clearly rules out the possibility of binding of the metal complex to DNA by intercalation, rather supports the proposition of groove binding by the complex …”