Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters

Subramani, Nagaraj; Manjappara, Uma V.

doi:10.1016/j.biochi.2016.03.009

Cited by 9 publications

(4 citation statements)

References 24 publications

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“…A possible hypothesis indicates that increased fat intake (exceeding the animal's metabolic capacity) may limit feed intake through fat‐induced feedback signals. Cholecystokinin (CCK) is the body's signal for satiety in many kinds of mammals (Nagaraj & Manjappara, 2016). Previous studies have shown that CCK significantly reduced the feed intake of HFD rats (Covasa & Ritter, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Growth, behavioural, serum biochemical and morphological changes in female rabbits fed high‐fat diet

Shao

Wang

et al. 2020

Animal Physiology Nutrition

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This study aimed to determine whether high‐fat diet (HFD) could cause growth, behavioural, biochemical and morphological changes in young female rabbits. Thirty‐six female rabbits were randomly divided into two groups fed with either a high‐fat diet (HFD) or a standard normal diet (SND) for 5 weeks. Growth and behavioural changes were recorded during the 5‐week feeding period. Tissue samples, including blood and adipose tissue, were obtained after slaughter. HFD rabbits weighed more by the end of the feeding period, had a higher percent body weight and adipose tissue weight change and had longer body and bust lengths than SND rabbits. HFD rabbits significantly reduced their feed intake and feeding frequency during the fourth and fifth weeks. HFD rabbits also showed lower frequency of drinking and resting and increased stereotypical behaviour. Besides, HFD rabbits showed significant physiological abnormalities. HFD rabbits had higher serum cholesterol (TC) and triglycerides (TG) levels than SND rabbits at the end of the feeding period, and higher free fatty acid (FFA) levels than rabbits in the SND group after the third week of feeding. Serum thyroxine (T4) increased significantly in week 2 and week 5 and triiodothyronine (T3) increased significantly in week four. However, there was no significant change in serum glucose (GLU) and insulin (INS) levels. Additionally, HFD reduced the area and diameter of perirenal and subcutaneous fat cells and increased their density. Our findings suggest that HFD rabbits had higher weight gains, accumulation of fat, and more behavioural changes than SND rabbits. Although high levels of fat in the diet had a low impact on hyperglycaemia, it could lead to hyperlipidemia and hyperthyroidism. Our results also suggest that sustained HFD may cause the proliferation of adipocytes in young female rabbits.

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Section: Discussionmentioning

confidence: 99%

“…Cholecystokinin (CCK) is the body's signal for satiety in many kinds of mammals (Nagaraj & Manjappara, 2016). Previous studies have…”

Section: Discussionmentioning

confidence: 99%

Growth, behavioural, serum biochemical and morphological changes in female rabbits fed high‐fat diet

Shao

Wang

et al. 2020

Animal Physiology Nutrition

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“…The results were expressed as means ± SEM (n = 6 animals/group). *P < 0.05; **P < 0.01. regulation of appetite and energy absorption (Nagaraj and Manjappara, 2016;ten Kulve et al, 2016;Dardzińska et al, 2017). Combining the expression characteristics of the chicken PCSK1 gene in the present study and the function of PC1/3 reported in mammals, it is reasonable to speculate that the function of PC1/3 in the chicken may be similar to that in mammals; therefore, chicken PC1/3 may process a variety of proneuropeptides and prohormones into functional hormones involved in the regulation of central and peripheral energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

Identification of a potential functional single nucleotide polymorphism for fatness and growth traits in the 3′-untranslated region of the PCSK1 gene in chickens1

Zhang

Cheng

Yang

et al. 2017

Journal of Animal Science

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Prohormone convertase 1/3 is a serine endoprotease belonging to the subtilisin-like proprotein convertase family that is encoded by the () gene, and its major function is the processing and bioactivation of the proproteins of many kinds of neuroendocrine hormones, including insulin, cholecystokinin, and adrenocorticotropic hormone. The results of our previous genomewide association study indicated that the gene might be an important candidate gene for fatness traits in chickens. The objectives of this study were to investigate the tissue expression profiles of gene and to identify functional variants associated with fatness and growth traits in the chicken. The results indicated that mRNA was widely expressed in various tissues, especially neuroendocrine and intestinal tissues. Of these 2 tissue types, mRNA expression in lean males was significantly higher than in fat males. A SNP in the 3' untranslated region of (c.*900G > A) was identified. Association analysis in the Arbor Acres commercial broiler population and Northeast Agricultural University broiler lines divergently selected for abdominal fat content (NEAUHLF) population showed that the SNP c.*900G > A was associated with abdominal fat weight, abdominal fat percentage, BW, metatarsus length, and metatarsal circumference. In the 5th to 19th generation (G to G) of NEAUHLF, the allele frequency of c.*900G > A changed along with selection for abdominal fat content. At G, allele G of c.*900G > A was predominate in the lean line, whereas allele A was predominate in the fat line. Functional analysis demonstrated that allele A of c.*900G > A reduced mRNA stability and consequently downregulated gene expression. These results suggested that c.*900G > A was a functional SNP for fatness and growth traits in the chicken. The results of this study provide basic molecular information for the role of gene in avian growth and development, especially obesity.

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“…As mentioned earlier, the possible involvement of GHS/ghrelin receptor signaling in the mediation of obestatin"s action was also suggested in correlation to its anorexigenic role and interaction with ghrelin on feeding behavior(26,78). This idea was further supported by an in vitro study, in which the administration of the ghrelin receptor antagonist [D-Lys3]-GHRP6 reduced the survival of β cells and human islet cells induced by obestatin(95). Furthermore, the administration of obestatin stimulated GHSR expression in vitro in pituitary cell cultures from baboons and mice, while it downregulated in mice, in vivo(160).Taken together, the present resultsthat the anxiogenic-and depressive-like effects of obestatin where reversed by the administration of a ghrelin receptor antagonistindicate that obestatin may act through GHSR signaling.…”

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confidence: 69%

Study of the effects of the ghrelin-associated peptide obestatin on stress-related behaviors

Szakács¹

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Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters

Cited by 9 publications

References 24 publications

Growth, behavioural, serum biochemical and morphological changes in female rabbits fed high‐fat diet

Growth, behavioural, serum biochemical and morphological changes in female rabbits fed high‐fat diet

Identification of a potential functional single nucleotide polymorphism for fatness and growth traits in the 3′-untranslated region of the PCSK1 gene in chickens1

Study of the effects of the ghrelin-associated peptide obestatin on stress-related behaviors

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