Studies on the influence of Bay K 8644 on hemodynamics and the size of a regional ischemia in isolated rabbit hearts

Rump, A.F.E.; Rösen, R.; Sigmund, Björn; Fuchs, Jens B.; Klaus, W.

doi:10.1016/0022-2828(92)91747-s

Journal of Molecular and Cellular Cardiology

1992

DOI: 10.1016/0022-2828(92)91747-s

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Studies on the influence of Bay K 8644 on hemodynamics and the size of a regional ischemia in isolated rabbit hearts

A.F.E. Rump¹,

R. Rösen²,

Björn Sigmund³

et al.

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Cited by 3 publications

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Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH fluorescence

Rump

Klaus

1994

Arch Toxicol

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Noradrenaline in a micromolar concentration has recently been shown to contribute to ischemic tissue injury by direct cardiotoxic effects independent of functional alterations. Oxygen free radicals, generated during the auto-oxidation of catecholamines, are important mediators of catecholamine cardiotoxicity. However, the role of the oxidative products (aminochromes) is still unclear. We examined the effects of adrenochrome on functional parameters and on regional myocardial ischemia (MI) in isolated electrically-driven rabbit hearts with depleted catecholamine stores (reserpine 7.0 mg/kg i.p. 16-24 h before preparation, Langendorff, constant pressure: 70 cm H2O, Tyrode solution, Ca++ 1.8 mmol/l, 37 degrees C). Repetitive MI, separated by a reperfusion period of 50 min, was induced by coronary artery branch ligature, and MI was quantitated from epicardial NADH fluorescence photography. Adrenochrome-treatment (10(-6) M or 10(-4) M) was started after a reperfusion period of 20 min. The left ventricular pressure (LVP) was significantly enhanced by adrenochrome (p < 0.05), but it fell thereafter to below its initial value in hearts treated with adrenochrome 10(-4) M. The global coronary flow (CF) was not affected by adrenochrome 10(-6) M (P > 0.05), but it was significantly decreased by adrenochrome 10(-4) M (P< 0.05). The relative CF (= CF/LVP x heart-rate) was numerically decreased by adrenochrome 10(-6) M (p > 0.05) and more markedly by adrenochrome 10(-4) M (p < 0.05). Whereas epicardial NADH fluorescence was similar after repetitive coronary artery occlusions in controls and in hearts treated with adrenochrome 10(-6) M (p > 0.05), it was significantly enhanced by adrenochrome 10(-4) M (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH fluorescence

Rump

Klaus

1994

Arch Toxicol

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Influence of (−)-S-Bay K 8644, (±)-Bay W 5035 and (±)-Bay T 5006 on hemodynamics and FITC-Dextran 3 elution kinetics in isolated rat hearts

Rump

Ratke²,

Fricke³

et al. 1993

General Pharmacology: The Vascular System

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Comparative effects of the Dihydropyridine-type calcium-agonists (−)-S-Bay K 8644, (±)-Bay-W 5035 and (±)-Bay-T 5006 on human platelet aggregability

Rump

Boller

Berkels

et al. 1994

General Pharmacology: The Vascular System

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Studies on the influence of Bay K 8644 on hemodynamics and the size of a regional ischemia in isolated rabbit hearts

Cited by 3 publications

References 0 publications

Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH fluorescence

Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH fluorescence

Influence of (−)-S-Bay K 8644, (±)-Bay W 5035 and (±)-Bay T 5006 on hemodynamics and FITC-Dextran 3 elution kinetics in isolated rat hearts

Comparative effects of the Dihydropyridine-type calcium-agonists (−)-S-Bay K 8644, (±)-Bay-W 5035 and (±)-Bay-T 5006 on human platelet aggregability

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