Studies on the hepatoprotective effects of rutin

Gilani, A.H.; Janbaz, Khalid Hussain; Saeed, Sheikh A.

doi:10.1016/1043-6618(95)86622-1

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute toxicity study and the effect of plant extract on pentobarbital-induced sleep was studied in Swiss albino mice (20-25g) as described in our earlier study (6). Different groups of 5 mice each were given graded doses of plant extract (0.5-3.0 g/kg, subcutaneously) and were kept under constant observation for 6 h to note any behavioral changes and mortality was recorded after 24 h of drug administration.…”

Section: Toxicity Evaluationmentioning

confidence: 99%

Hypotensive Constituents from the Pods ofMoringa oleifera

Faizi

Siddiqui²,

Saleem³

et al. 1998

Planta Med

142

View full text Add to dashboard Cite

Hypotensive activity of the ethanolic and aqueous extracts of Moringa oleifera whole pods and their parts, namely, coat, pulp, and seed was investigated. The activity of the ethanolic extract of both the pods and the seeds was equivalent at the dose of 30 mg/kg. The ethyl acetate phase of the ethanolic extract of pods was found to be the most potent fraction at the same dose. Its bioassay-directed fractionation led to the isolation of thiocarbamate and isothiocyanate glycosides which were also the hypotensive principles of the pods as observed in case of Moringa leaves. Two new compounds, O-[2'-hydroxy-3'-(2"-heptenyloxy)]-propyl undecanoate (1) and O-ethyl-4-[(alpha-L-rhamnosyloxy)-benzyl] carbamate (2) along with the known substances methyl p-hydroxybenzoate (3) and beta-sitosterol have also been isolated in the present studies. The latter two compounds and p-hydroxybenzaldehyde showed promising hypotensive activity. Structures of all these compounds have been deduced by spectroscopy and chemical reactions.

show abstract

Section: Toxicity Evaluationmentioning

confidence: 99%