1963
DOI: 10.1002/bscb.19630721113
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Studies on the Grignard Reaction‐VI. Steric Effects in the Grignard Addition Reaction on Ketones

Abstract: The reactivity in the normal Grignard addition reaction is greatly reduced when the ketone is branched in the α‐position. Alkylation in β‐position has only slight effect and in the γ‐position there is no effect at all.

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