Studies on the Genotoxic Properties of Essential Oils with<i>Bacillus subtilis rec</i>-Assay and<i>Salmonella</i>/Microsome Reversion Assay

Zani, Franca; Massimo, G.; Benvenuti, Stefania; Bianchi, Alberto; Albasini, A.; Melegari, Margherita; Vampa, G; Bellotti, Anna; Mazza, P

doi:10.1055/s-2006-960081

Cited by 80 publications

(41 citation statements)

References 6 publications

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“…sativum, A. absinthium, C. regalis, C. carvi, I. helenium, J. regia, S. hortensis, and V. officinalis showed the best activity against the infective third-stage larvae of T. colubriformis in the LMI test, and a significant anthelmintic effect on egg embryogenesis (A. suum) was demonstrated by extracts from A. sativum, A. absinthium, C. carvi, D. carota, and J. regia. In summary, based on the results of the above-described experiments and literature data indicating low levels of toxicity for extracts from A. sativum (Saxena et al, 2005;Velasco-Velázquez et al, 2006), A. absinthium (Chiasson et al, 2001;Muto et al, 2003), C. carvi (Kumar & Singh, 2006), I. helenium (Spiridonov et al, 2005;Dorn et al, 2006), J. regia (Inbaraj & Chignell, 2004;Bhatia et al, 2006), S. hortensis (Zani et al, 1991), and V. officinalis (Romero-Jimenez et al, 2005;Yao et al, 2007), we suggest that some of these plant materials could be prospective sources for development of new antiparasitical herbal remedies. However, further phytochemical studies are required to determine the types of compounds responsible for the anthelmintic properties of these species.…”

Section: Discussionmentioning

confidence: 54%

In VitroAnthelmintic Effects of Medicinal Plants Used in Czech Republic

Urban

Kokoška

Langrová

et al. 2008

Pharmaceutical Biology

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The ethanol extracts of 16 Czech medicinal plants, namely, . sativum, A. absinthium, C. carvi, D. carota, and J. regia possessed the strongest anthelmintic effect on the embryonating eggs at all concentrations tested (62.5, 125, 250, 500, 1000, 2000 µg/mL). The best results, showing a higher effect against the infective third-stage larvae in comparison with synthetic anthelmintic Zentel (albendazole), have been obtained for A. sativum, A. absinthium, C. carvi, C. regalis, I. helenium, J. regia, S. hortensis, and V. officinalis.

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Section: Discussionmentioning

confidence: 54%

In VitroAnthelmintic Effects of Medicinal Plants Used in Czech Republic

Urban

Kokoška

Langrová

et al. 2008

Pharmaceutical Biology

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“…Several studies with various essential oils or their main components have demonstrated that, generally, most of them did not induce nuclear mutations (Bakkali et al 2008). However, some exceptions should be identified, such as Artemisia dracunculus oil (Zani et al 1991), Mentha spicata oil (Karpouhtsis et al 1998), Anethum graveolens oil and Pinus sylvestris oil (Lazutka et al 2001). In the present study, the MNPCE frequency of C. guianensis oil treated groups was very similar to negative control, suggesting that C. guianensis oil show no genotoxic activity for all doses tested (250, 500, and 1.000 mg/kg bw).…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

Lemes

Chaves

Silva

et al. 2017

An. Acad. Bras. Ciênc.

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The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct-and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/ kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow. Regarding the antimutagenic effect, all doses of C. guianensis oil were significantly (p < 0.05) effective in reducing the frequency of micronucleated polychromatic erythrocytes, when compared with MMC or CP alone. Based on these results, our results suggest that the C. guianensis oil shows medicinal potential as an antimutagenic agent, modulating the mutagenicity caused by both direct-and indirect-acting chemical mutagens, in a mammalian model.

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“…Genotoxic properties of the essential oils of S. hortensis and S. montana were studied with Bacillus subtilis rec-assay and Salmonella/microsome reversion assay by Zani et al (1991). Both oils exhibited moderate activity in rec-assay and Salmonella tests.…”

Section: Genotoxic Activitymentioning

confidence: 99%

A pharmacological and phytochemical overview onSatureja

Tepe

Çilkiz

2015

Pharmaceutical Biology

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Context: Satureja (Lamiaceae) species are used as flavoring compounds in food, pharmaceutical, and cosmetic industries because of its sweetness and simple cultivation characteristics. They have traditionally been used as muscle pain relievers, tonic, and carminative agents to treat stomach and intestinal disorders such as cramps, nausea, indigestion, and diarrhea, due to their considerable phytochemical characteristics. Objective: This review evaluates some information published since 1989 on Satureja genus from a systematic perspective in terms of its pharmacological and phytochemical characteristics. Materials and methods: Web of Science, PubMed, Scopus, and Google Scholar databases were searched up to March 2014. ''Satureja'' was used as a research term without narrowing or limiting research elements. After obtaining all reports from database (a total number is about 637), the papers were carefully analyzed in order to find data related to the topic of this review. Results: In this review, 453 reports were used which were published between 1989 and 2014. The study was compiled into two sections (Pharmacology and Phytochemistry). In the pharmacology section, more than 50 different activities were studied. In the second section, in addition to other compounds and inorganic substances, volatiles, phenolic acids, and flavonoids were discussed. Discussion and conclusion: According to our contemporary information, Satureja species have been evaluated for their wide range of biological activities. However, a small part of these studies have been carried out on the active principles. Therefore, in the future, more studies should be carried out to identify responsible phytochemicals for the various activities.

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Studies on the Genotoxic Properties of Essential Oils withBacillus subtilis rec-Assay andSalmonella/Microsome Reversion Assay

Cited by 80 publications

References 6 publications

In VitroAnthelmintic Effects of Medicinal Plants Used in Czech Republic

In VitroAnthelmintic Effects of Medicinal Plants Used in Czech Republic

Antigenotoxicity protection of Carapa guianensis oil against mitomycin C and cyclophosphamide in mouse bone marrow

A pharmacological and phytochemical overview onSatureja

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