Studies on the Functional Role of Adenosine 3', 5'-Monophosphate, Histamine and Prostaglandin E1 in the Central Nervous System

Asakawa, Takeo; Yoshida, Hiroshi

doi:10.1254/jjp.21.569

Cited by 17 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that activities of adenylate cyclase and cyclic nucleotide phosphodiesterase are higher in brain tissue than in other tissues (1)(2)(3), and regulatory roles of 3',5'-cyclic adenosine monophosphate (cyclic AMP) on brain function have been reported by several workers (4)(5)(6)(7)(8)(9)(10)(11) was increased by addition of 5 mM dibutyryl cyclic AMP and 1 mM theophylline, though theophylline did not increase the ACh release. Dibutyryl cyclic AMP alone also showed a stimulatory effect on the ACh release, but the effect seemed to be variable.…”

mentioning

confidence: 99%

Increase in ACh Release from the Rat Brain Cortex Slices by 3’,5’-Cyclic Adenosine Monophosphate

Katsuki

Matsuda

Hata

et al. 1977

Japanese Journal of Pharmacology

Self Cite

View full text Add to dashboard Cite

mentioning

confidence: 99%

Increase in ACh Release from the Rat Brain Cortex Slices by 3’,5’-Cyclic Adenosine Monophosphate

Katsuki

Matsuda

Hata

et al. 1977

Japanese Journal of Pharmacology

Self Cite

View full text Add to dashboard Cite

“…ln.our previous studies (17,18), young chicks were used to elucidate the effects of cyclic AMP, biogenic amines and prostaglandins on the central nervous system. We favored young chicks rather than mammals as experimental animals as it was possible to show the re markable effects of cyclic AMP on locomotor activity quantitatively, and to observe that remarkable effects began to appear in 20 sec to one min after intracerebral administration.…”

mentioning

confidence: 99%

F-Induced Changes and Its Reversal by Itp in Membrane Turbidity and Adenylate Cyclase Activity of Chick Brain Microsomes

Asakawa

Yoshida

1976

Japanese Journal of Pharmacology

Self Cite

View full text Add to dashboard Cite

Abstract-The activation of adenylate cyclase by NaF was dependent on the previous incubation time and the concentration of F-. The activation by F was irreversible and Mg2+ was required for the maximum effect. Turbidity of microsome suspension was also greatly increased by F plus Mg"'. These effects on adenylate cyclase and membrane turbidity were specific for F and F--saturation curves for both were similar, though Mg' -saturation curves for both were dissimilar.The increase in turbidity induced by F plus Mg=` was rapidly reversed by ATP, GTP, ITP, UTP and CTP. However, ITP only, among all the triphospho-nucleotides tested, reversed the activity of adenylate cyclase previously activated by NaF plus MgCI2. The activity of the enzyme reversed by ITP was not, however, re-enhanced by the presence of NaF in the assay medium. These results suggest the possibility that F induces a change in the membrane structure itself, and this change can be reversed by incubation with ITP.

show abstract

Role of Cyclic Nucleotides in the Nervous System

Daly

1975

Synaptic Modulators

View full text Add to dashboard Cite

Studies on the Functional Role of Adenosine 3', 5'-Monophosphate, Histamine and Prostaglandin E1 in the Central Nervous System

Cited by 17 publications

References 47 publications

Increase in ACh Release from the Rat Brain Cortex Slices by 3’,5’-Cyclic Adenosine Monophosphate

Increase in ACh Release from the Rat Brain Cortex Slices by 3’,5’-Cyclic Adenosine Monophosphate

F-Induced Changes and Its Reversal by Itp in Membrane Turbidity and Adenylate Cyclase Activity of Chick Brain Microsomes

Role of Cyclic Nucleotides in the Nervous System

Contact Info

Product

Resources

About