Studies on the Fate of Virulent and Avirulent Staphylococci in Mice

Smith, J. Maclean

doi:10.1111/j.1749-6632.1956.tb36624.x

Cited by 9 publications

(2 citation statements)

References 3 publications

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“…The kidney is the site of maximum multiplication in numerous other experimental infections, including those due to staphylococci (19), Mycobacteriumi fortuitum (20), and Corynebacteriun renale (21). The mechanisms underlying the renal susceptibility to infection have not been delineated.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Cortisone on Experimental Fungus Infections in Mice*

Louria¹,

Fallon²,

Browne³

1960

J. Clin. Invest.

141

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The administration of adrenal glucocorticoids is associated with enhancement of many experimental infections. The pertinent studies have been reviewed comprehensively by Kass and Finland (1). Most experiments in which fungi were used as the infecting microorganism have also demonstrated an increase in the severity of infection when adrenal hormones were injected prior to or concomitantly with the fungus (2-9). A few studies, however, showed no augmentation of mycotic disease following the administration of steroids (3, 10-12).The investigations on fungi have not provided information as to the relative propensity of the various species to disseminate under the influence of steroids, nor have they offered definitive data on the mechanisms of enhancement or on the tissue localization of increased infection.

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Section: Discussionmentioning

confidence: 99%

The Influence of Cortisone on Experimental Fungus Infections in Mice*

Louria¹,

Fallon²,

Browne³

1960

J. Clin. Invest.

141

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“…The staphylococci were the Smith strain of coagulase-positive Staph. aureus (originally obtained by Dubos from a patient with osteomyelitis), maintained by in uitro passage in the laboratory (Smith & Dubos, 1956a, Smith, 1956. Other strains obtained from infected patients in the University of Iowa Hospitals have been used occasionally and they produce similar effects to those of the Smith strain.…”

mentioning

confidence: 99%

Metabolic Response of the Host to Staphylococcal Infection*

Smith

1965

Annals of the New York Academy of Sciences

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Observations on Staphylococcus Albus Septicemia in Mice and Men

Smith¹

1958

Arch Intern Med

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Porcelain-white colonies of Staphylococcus albus in cultures from patients usually are dismissed as nonpathogenic commensals or as contaminants. The recent occurrence of S. albus septicemia in three patients after valvulotomy for mitral stenosis led us to reexamine this subject.Reviews of subacute bacterial endocarditis both in the past and recently show that approximately 1% of cases are caused by S. albus. A survey 36 of cases of staphylococcal bacteremia at this hospital in the years 1936 to 1955 showed that 5 of the 338 cases were caused by this organism. The criteria used for the diagnosis of S. albus septicemia in this study are that the organism should be isolated on two or more occasions from the blood of a sick person with evidence of generalized disease and that no other pathogens should be isolated from the blood. S. albus has for the purpose of this study been accepted as an organism which produces porcelain-white or indifferently colored colonies but never produces a yellow or golden pigment. In the four strains studied in detail mannitol was not fermented and coagulase was not formed.To the five cases from the records at the University

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Studies on the Fate of Virulent and Avirulent Staphylococci in Mice

Cited by 9 publications

References 3 publications

The Influence of Cortisone on Experimental Fungus Infections in Mice*

The Influence of Cortisone on Experimental Fungus Infections in Mice*

Metabolic Response of the Host to Staphylococcal Infection*

Observations on Staphylococcus Albus Septicemia in Mice and Men

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