Studies on the Environmental Control of Laboratory Animals.

Yamauchi, Chuhei

doi:10.1538/expanim.44.9

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…In order to obtain reliable and sustainable results, genetically and microbiologically defined pedigrees are needed, as well as having a good laboratory animal laboratory. Moreover, infectious diseases in experimental animals must be kept under control and safe conditions must be provided for researchers and other employees (18)(19)(20)(21)(22). Biological risk assessment is a key factor in safe laboratory work.…”

Section: Safe Working With Experimental Animalsmentioning

confidence: 99%

Animal Experiments and Laboratory Safety within the Scope of Occupational Health and Biosafety

Uçak

2024

Düzce Tıp Fakültesi Dergisi

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Occupational health and biosecurity terms include scientific approaches regarding ethical values, reliable methods, and a series of precautions to be taken against risks and hazards for employees and the living material being studied. Research and development activities carried out within the scope of biotechnology involve many risks under laboratory conditions, which are their own physical area. Many precautions and practices have been defined to analyze these risks and take precautions before they occur, and laboratory guides have been created in line with these definitions. During studies carried out with experimental animals under laboratory conditions, safe working rules may be violated due to physical conditions, equipment and materials, treatments applied to the subjects, negligence, or faulty practices caused by the researcher or expert. Biosafety in animal experiments consists of a set of ethical conditions and practices declared in the guidelines of specialized laboratories at their own level, protecting employees, subjects, and life outside the laboratory. In this review, possible risks and dangers that may arise at different biosafety levels and the precautions and practices that can be taken against them are evaluated. In this way, it was aimed to contribute to the development of laboratory and biosafety criteria in animal experiments.

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Section: Safe Working With Experimental Animalsmentioning

confidence: 99%

Animal Experiments and Laboratory Safety within the Scope of Occupational Health and Biosafety

Uçak

2024

Düzce Tıp Fakültesi Dergisi

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“…Studies using laboratory animals have great merits in that the research environment can be controlled [4]. In addition to supplying drinking water and food; preventing exposure to the external environment; and controlling light, temperature, humidity, and noise; the age of the laboratory animal can be selected according to the study situation [5].…”

Section: Introductionmentioning

confidence: 99%

Phenotype of the Aging-Dependent Spontaneous Onset of Hearing Loss in DBA/2 Mice

Seo

Lee

Kang

et al. 2021

Veterinary Sciences

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DBA/2 mice are a well-known animal model for hearing loss developed due to intrinsic properties of these animals. However, results on the phenotype of hearing loss in DBA/2 mice have been mainly reported at an early stage in mice aged ≤7 weeks. Instead, the present study evaluated the hearing ability at 5, 13, and 34 weeks of age using DBA/2korl mice. Auditory brainstem response test was performed at 8–32 KHz at 5, 13, and 34 weeks of age, and hearing loss was confirmed to be induced in a time-dependent manner. In addition, histopathological evaluation at the same age confirmed the morphological damage of the cochlea. The findings presented herein are the results of the long-term observation of the phenotype of hearing loss in DBA/2 mice and can be useful in studies related to aging-dependent hearing loss.

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“…이와는 반대로 환경적 요인이 엄격히 컨트롤된 표준적인 실험조건을 갖춘 각기 다른 동물실험시설 혹은 동일한 시설에서 다른 시기에 실 험을 실시하여 얻어진 실험결과들을 비교한 결과, 환경조 건의 표준화에 의해 결과의 변동폭 감소와 함께 재현성 이 높은 결과가 얻어졌다 (Golberg, 1974;Chvedoff et al, 1980). (Yamauchi, 2008). 기후적 요인은 실험결과 뿐 아니라, 실험동물의 번식 및 육성에 도 악영향을 미치는 것으로 보고되어있기 때문에 생산시 설에서도 철저한 관리가 필요하다 (Barnett, 1965;Ulberg and Burfening, 1967;Barnett, 1973 (Broderson et al, 1976).…”

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The Need for the Introduction of Assessment Program of Good Animal Care and Use Facility

Lee

Cha

2010

Lab Anim Res

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Studies on the Environmental Control of Laboratory Animals.

Cited by 4 publications

References 28 publications

Animal Experiments and Laboratory Safety within the Scope of Occupational Health and Biosafety

Animal Experiments and Laboratory Safety within the Scope of Occupational Health and Biosafety

Phenotype of the Aging-Dependent Spontaneous Onset of Hearing Loss in DBA/2 Mice

The Need for the Introduction of Assessment Program of Good Animal Care and Use Facility

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