Studies on the electron transport system XXVI. Specificity of coenzyme Q and coenzyme Q derivatives

Ambe, K. S.; Crane, F.L.

doi:10.1016/0006-3002(60)90403-0

Cited by 23 publications

(7 citation statements)

References 17 publications

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“…It would be interesting to know if the lack of activity of 2,3-diethoxy Ubiquinone or the 2,3-diamyloxy Ubiquinone refl ects specificity in the quinone reductase or dehydrogenase (23,24). The lack of specifi city for succinoxidase indicates a second type of dehydrogenase.…”

Section: Specificity Of Uhiquinol Dehydrogenasementioning

confidence: 99%

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Hydroquinone Dehydrogenases

Crane¹

1977

Annu. Rev. Biochem.

159

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Section: Specificity Of Uhiquinol Dehydrogenasementioning

confidence: 99%

“…A num ber of specific inhibitors have long been known to inhibit electron transport between cytochrome b and C I (24,25). These include antimycin, 2-alkyl-4hydroxyquinoline-N-oxide, BAL, and 2-alkyl-3-hydroxynaphthoquinones (SN5949).…”

Section: Inhibitors Of Ubiquinol-cytochrome C Reductasementioning

confidence: 99%

Hydroquinone Dehydrogenases

Crane¹

1977

Annu. Rev. Biochem.

159

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“…Changes in PQ absorption at 265 nm in response to bicarbonate removal also indicates two sites for PQ function between photosystems, but does not identify which PQs are involved (Siggel et al 1977; for a review on the role of bicarbonate in the PQ region, see Van Rensen et al 1999). Extraction of mitochondria by acetone, to remove quinones, showed a specific requirement for coenzyme Q (Ambe and Crane 1960). In chloroplasts, Henninger and Crane (1963) found that acetone extraction removed all of the PQA and PQB, but left 50% of the PQC and PQD; this difference implies a tight binding site for PQC.…”

Section: Different Plastoquinones Including the Story Of The Christmamentioning

confidence: 99%

Discovery of plastoquinones: a personal perspective

Crane

2010

Photosynth Res

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The discovery and the rediscovery of plastoquinone (PQ) are described together with the definition of its structure as a 2,3-dimethyl 5 solanosyl benzoquinone. The discovery, by M. Kofler, was a result of a search for Vitamin K. Its rediscovery was made by me, when I was at The Enzyme Institute of the University of Wisconsin, analyzing animals and plants for the newly discovered coenzyme Q. In green plants, I found another lipophilic quinone in addition to coenzyme Q. Some misleading evidence suggested as if the new quinone had coenzyme Q activity in mitochondria, but improved methods gave negative results. When I found that the quinone was concentrated in chloroplasts, I considered a role for it in photosynthesis analogous to the role of coenzyme Q in mitochondria. After moving to the Chemistry Department, University of Texas at Austin, I used a plain light bulb and some spinach chloroplasts to show that PQ could be involved in photosynthetic redox reactions. This effect was supported by Norman Bishop's restoration of chloroplast electron transport after solvent extraction, with PQ and photoreduction studies by E. R. Redfern and J. Friend in R. A. Morton's laboratory in Liverpool, UK. We also found an additional analog of PQ in addition to a second analog found in Wisconsin. We called the new analogs PQB and PQC. Although we found some restoration effects with PQC, the discovery by W. T. Griffiths in Morton's laboratory, that PQB and PQC consisted of six forms of PQ each, made it more likely that the new analogs were breakdown products. Morton's group established the structure of the PQCs as a series of PQs, with a hydroxyl group on the prenyl side chain, and the PQB series as having fatty acids esterified to the hydroxyl groups of PQC. Possible functions of the analogs are also discussed in this article.

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“…Solvent extraction procedures have been immensely useful in studying coenzyme Q function (134,135). The same type of process was successfully used by Lynch & French (136) to extract lipids from chloroplasts and show restoration of activities when the lipid was re-added.…”

Section: Functional Lipid Moleculesmentioning

confidence: 98%

“…Ambe & Crane (135) have shown that the restorative effects of coenzyme Q for succinic-cytochrome-c reductase activity are specific to the quinone moiety. Certain other lipid factors (146) have also been found to be rather specific in their function, and induction of a requirement correlates with an appearance in the extracting solvent.…”

Section: Functional Lipid Moleculesmentioning

confidence: 99%

Structure and Function of Mitochondria

Crane¹

1961

Annu. Rev. Plant. Physiol.

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Studies on the electron transport system XXVI. Specificity of coenzyme Q and coenzyme Q derivatives

Cited by 23 publications

References 17 publications

Hydroquinone Dehydrogenases

Hydroquinone Dehydrogenases

Discovery of plastoquinones: a personal perspective

Structure and Function of Mitochondria

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