Studies on the Effects of the Extirpation of the Submandibular and Sublingual Glands on the Secretory Function of the Parotid Gland Cells and on Histamine in the Blood

Kawai, Tadao

doi:10.1679/aohc1950.14.397

Cited by 2 publications

(1 citation statement)

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“…The contraction of MEC processes assists in saliva secretion by loading pressure on acini [36]. Since salivary gland tissue was decreased by surgery, residual tissues are required to compensate for saliva secretion to maintain the secretory volume [18, 19]. Secretory function was enhanced in salivary glands after excision of the same and/or other salivary glands in rats [18, 19], and in humans [9].…”

Section: Discussionmentioning

confidence: 99%

Morphological Changes of Myoepithelial Cells in the Rat Submandibular Gland Following the Application of Surgical Stimuli

Kawabe

Mizobe

Bando

et al. 2016

Acta Histochemica et Cytochemica

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Myoepithelial cells (MECs) exist on the basal surface of acini in major exocrine glands, include myofilaments and various constructive proteins, and share characteristics with smooth muscle and epithelial cells. MECs project several ramified processes to invest acini, and possibly contract to compress acini to support the secretion by the glandular cells. However, the functional roles of MECs in salivary secretion are still unclear. We investigated morphological changes in immunostained MECs using the anti-α-smooth muscle actin (αSMA) antibody in operated or non-operated contralateral (NC) submandibular glands after partial or total resection. Furthermore, we investigated and discuss other salivary glands of rats. MECs in the parotid, sublingual and submandibular gland of adult rats exhibited different shapes and localizations. After surgery, in both operated and NC glands, the number of MECs and αSMA-immunopositive areas increased significantly. Three-dimensional analysis using a confocal laser-scanning microscope revealed that substantial and significant enhancement became evident in the number, length, and thickness of MEC-processes covering acini of the operated and NC submandibular glands. The preset findings indicate that MECs alter the morphology of their processes in operated and NC glands after surgery of the partial or total resection. It is suggested that MECs promote salivary secretion using elongated, thickened, and more ramified processes.

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