FUJIE, one of the authors, has found that the vacuoles which fill the lower half of the gastric surface cells of unfed rats decrease rapidly in the cells after administration of the diet. He found also an imidazol group in the vacuoles by the use of chemical colour reactions according to the histochemical method. As a result of his studies, it was proved that the substance in the vacuoles promotes haematogenously the production of secretory granules in the gastric peptic cells and in the pancreatic cells. He proposed the substance in the vacuoles be given the name productin (FUJIE) (1952).The recent studies of FUJIE et al. in which the alcohol-ether extract of the su-