Studies on the Effect of Gallate on the Oxidation of Aldehydes Dispersed in Cetomacrogol Solutions

Wan, Lucy S.C.; Hwang, C.L.

doi:10.1002/jps.2600580233

Cited by 7 publications

(2 citation statements)

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“…Some compounds like 1, 3, 7, 9-10, 22, 25, 27, 29, 34, 39, and 41-42 were found to be strong antioxidant and showed IC 50 values ranging from 24 to 30 lg ⁄ mL while others showed low antioxidant activity ( Table 4). The compounds (e.g., 3 and 9) with good antitumor activity were found to be strong antioxidants as well, and these results are consistent with the previous reports of some correlations found in these two activities (24 Biological Activities of Some Semicarbazones literature (25,26). Furthermore, it was noted that these two compounds (12 and 17) have shown DNA protective activity but no antioxidant activity (27).…”

Section: Dna Damaging Studiessupporting

confidence: 90%

Microwave‐assisted Synthesis and Bioevaluation of Some Semicarbazones

et al. 2012

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In continuation to our efforts in finding potential therapeutic agents, a variety of biologically significant semicarbazones were synthesized by the reaction of different carbonyl compounds with phenyl semicarbazides through microwave irradiation. Initially, 18 semicarbazones were studied for their antimicrobial, antitumor, and antioxidant potential. None of the tested compounds showed any antibacterial activity; however, some compounds showed significant antifungal activity. Interestingly, all compounds showed antitumor activity when tested against tumors grown on potato discs. These compounds were also tested for their effect on OH radical-induced oxidative DNA damage. All the compounds showed DNA protection to varying extent. Based on the promising results of antitumor and antioxidant activities, another set of 24 semicarbazones was synthesized, and all of these semicarbazones were evaluated for their antioxidant potential. The results showed that the semicarbazones derived from 2-nitrobenzaldehyde and acetophenone were the most active 2,2-diphenyl-1-picrylhydrazyl 9 (DPPH) free radical scavengers. The overall results have led to the identification of some interesting compounds which seem to have great potential to be developed into effective anticancer drugs.

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Section: Dna Damaging Studiessupporting

confidence: 90%

Microwave‐assisted Synthesis and Bioevaluation of Some Semicarbazones

et al. 2012

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“…Propyl gallate containing patch induced the highest decomposition of THC. Usually, the more antioxidant added, the more protection it offers, however, higher antioxidant concentrations of propyl gallate have been reported to accelerate oxidation 17. Since, phenolic antioxidants were not effective in inhibiting the oxidation, it may be assumed that the peroxy radicals were not significantly involved in the oxidation chain reaction.…”

Section: Resultsmentioning

confidence: 99%

Polymeric Systems for Amorphous Δ9-Tetrahydrocannabinol Produced by a Hot-melt Method. Part II: Effect of Oxidation Mechanisms and Chemical Interactions on Stability

Munjal

ElSohly

Repka

2006

Journal of Pharmaceutical Sciences

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The objectives of the present research investigations were to (i) elucidate the mechanism for the oxidative degradation of Δ 9 -tetrahydrocannabinol (THC) in polymer matrix systems prepared by a hot-melt fabrication procedure, and (ii) study the potential for controlling these mechanisms to reduce the degradation of THC in solid dosage formulations. Various factors considered and applied included drug-excipient compatibility, use of antioxidants, cross-linking in polymeric matrices, microenvironment pH, and moisture effect. Instability of THC in polyethylene oxide (PEO)-vitamin E succinate (VES) patches was determined to be due to chemical interaction between the drug and the vitamin as well as with the atmospheric oxygen. Of the different classes and mechanisms of antioxidants studied, quenching of oxygen by reducing agents, namely, ascorbic acid was the most effective in stabilizing THC in PEO-VES matrices. Only 5.8% of the drug degraded in the ascorbic acid-containing patch as compared to the control (31.6%) after 2 months of storage at 40°C. This coupled with the cross-linking extent and adjustment of the pH microenvironment, which seemed to have an impact on the THC degradation, might be effectively utilized towards stabilization of the drug in these polymeric matrices and other pharmaceutical dosage forms. These studies are relevant to the development of a stable transmucosal matrix system for the therapeutic delivery of amorphous THC.

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