Studies on the Development of Colon Targeted Oral Drug Delivery Systems for Ornidazole in the Treatment of Amoebiasis

Abstract

The aim of the present study is to develop colon-targeted drug delivery systems for ornidazole using guar gum as a carrier. The core formulation containing ornidazole was directly compressed. Compression-coated tablets of ornidazole containing various proportions of guar gum in the coat were prepared. All the formulations were evaluated for hardness and drug content uniformity and were subjected to in vitro drug release studies. The amount of ornidazole released from tablets at different time intervals was estimated by the HPLC method. The compression-coated formulations released less than 8% of ornidazole in the physiological environment of stomach and small intestine. The compression-coated tablets with 85%, 75%, and 65% of guar gum coat released about 21%, 38%, and 73% of ornidazole, respectively, in simulated colonic fluids indicating the susceptibility of the guar gum formulations to the rat caecal contents. The results of the study show that compression-coated ornidazole tablets with either 65% (OLV-65) or 75% (OLV-75) of guar gum coat are most likely to provide targeting of ornidazole for local action in the colon owing to its minimal release of the drug in the first 5 hr. The ornidazole compression-coated tablets showed no change in physical appearance, drug content, or in dissolution pattern after storage at 40 degrees C/75% relative humidity for 6 months.

Thermotropic and Spectroscopic Behavior of Skin: Relationship with Percutaneous Permeation Enhancement

“…The chemical modification of monoterpenes d-limonene and pinene to their oxides was found to enhance the in vitro permeation of lipophilic molecule haloperidol across human SC [41]. Carvone enhanced the in vitro percutaneous permeation of tamoxifen across porcine epidermis [93], nicardipine hydrochloride across rat skin [95] and nimodipine from hydroxypropyl methylcellu- lose gel across rat skin [96,154]. L-menthol has been found to facilitate in vitro permeation of morphine hydrochloride through hairless rat skin [127], imipramine hydrochloride across rat skin [98], hydrocortisone through hairless mouse skin [155], nicardipine hydrochloride across excised rat epidermis from hydroxypropyl cellulose gels [94] and nimodipine from membrane-moderated transdermal therapeutic system [156].…”

An overview of the recent developments in analytical methodologies for determination of COX-2 inhibitors in bulk drugs, pharmaceuticals and biological matrices

“…RP-LC, MEKC and chemometric methods were developed for the stability-indicating assay and validated [141][142][143]. Monolithic ODS columns and post column chemical derivatization techniques using spectrophotometric, fluorimetric and tandem mass spectrophotometric detectors for estimation of RXB in bulk drugs, formulations including the human plasma were developed [134,[144][145][146][147][148][149][150][151][152][153][154]. The conditions are discussed in Table 3E.…”

Newer Methods of Nanoparticle Synthesis: Nitroimidazole properties with Nanometal oxides in Polymer Cages as Drug-Biomarker Monitors

“…Nitroimidazole polymer complexes as hydrogels, beads used as colon targeted drug delivery systems is emerging [1,3,6,11,13,14,15,17,22]. Different polymers such as polyethylene glycol [9,20], poly vinyl alcohol [4,24], polymethylmethacrylate [16],polysaccharides [6,11].…”