Studies on the Coulter counter Part I. Investigation into the effect of orifice geometry and flow direction on the measurement of particle volume

Karuhn, R.; Davies, R.; Kaye, Brian H.; Clinch, M.J.

doi:10.1016/0032-5910(75)80040-4

Cited by 23 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4][5][6] This technique detects the brief change in resistance of a small orifice immersed in salt solution when a particle passes it either by a pressure-driven or voltage-driven flow. The wellknown Coulter counter uses this principle to count and size, e.g., blood cells or even viruses.…”

Section: Introductionmentioning

confidence: 99%

Modeling of colloidal transport in capillaries

Stober

Steinbock

Keyser

2009

Journal of Applied Physics

View full text Add to dashboard Cite

We dynamically model the full ionic current signature of micron-sized colloids passing through microcapillaries in silico for the first time. Our novel computer simulation allows free adjustment of all relevant experimental parameters such as the geometry of the used orifice, noise sources, external applied pressure or voltage, and the charge of the particles passing through the channel. We demonstrate that our algorithm correctly describes the experimentally observed signals in our recently introduced microcapillary based Coulter counters. Finally, we quantitatively investigate the influence of DNA-functionalized particles on the signal amplitude as a function of salt concentration and particle size.

show abstract

Section: Introductionmentioning

confidence: 99%

Modeling of colloidal transport in capillaries

Stober

Steinbock

Keyser

2009

Journal of Applied Physics

View full text Add to dashboard Cite

show abstract

“…This will increase the force and position resolution as compared to the membrane nanopore setups, where the displacement of the colloid has to be detected along the optical axis. 2 Conclusion. We have been discussing a nanocapillarybased Coulter counter for the detection of λ-DNA molecules.…”

mentioning

confidence: 99%

“…It provides a means for the label-free characterization of microand nanoparticles in solution. [1][2][3] Early experiments revealed that it is possible to count and size bacteria cells with a Coulter counter. 4 Subsequently, the application range was expanded to particles such as pollen, viruses, or colloids coated with, e.g., antibodies.…”

mentioning

confidence: 99%

“…The resistive pulse principle forms the technical basis for the well-known Coulter counter. It provides a means for the label-free characterization of micro- and nanoparticles in solution. − Early experiments revealed that it is possible to count and size bacteria cells with a Coulter counter . Subsequently, the application range was expanded to particles such as pollen, viruses, or colloids coated with, e.g., antibodies. , The recent miniaturization of the sensing volume, with the help of solid-state or biological nanopores has extended the range of detection to single biomolecules. − The Coulter counter technique is based on two reservoirs, both filled with a particle-laden salt solution and connected by a single orifice.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Detecting DNA Folding with Nanocapillaries

et al. 2010

View full text Add to dashboard Cite

We demonstrate for the first time the detection of the folding state of double-stranded DNA in nanocapillaries with the resistive pulse technique. We show that glass capillaries can be pulled into nanocapillaries with diameters down to 45 nm. We study translocation of lambda -DNA which is driven by an electrophoretic force through the nanocapillary. The resulting change in ionic current indicates the folding state of single lambda -DNA molecules. Our experiments prove that nanocapillaries are suitable for label-free analysis of DNA in aqueous solutions and viable alternatives to solid-state nanopores made by silicon nanotechnology.

show abstract

“…Normally, particles with diameters ranging from 2% to a maximum size of 40-60% are noted by different studies to be reliably detected [64,166,170,171,181]. The signals of smaller particles are lost due to the signal-to-noise ratio; particles larger than 40-60% give an increasingly nonlinear response and can physically block the orifice [166,170,[181][182][183][184]. The selected orifice diameter can then be estimated based on the particle sizes.…”

Section: Electrical Sensing Zone Methods (Coulter Counter)mentioning

confidence: 99%

Online Quality Measurements of Total Suspended Solids for Offshore Reinjection: A Review Study

Hansen

Bram

Lauridsen³

et al. 2021

Energies

View full text Add to dashboard Cite

The importance and awareness of accurate online water quality measurements increase every year in the oil and gas sector, whether it is for reducing oil discharge, preparing produced water for reinjection, or improving operational performance. For online measurement techniques to yield valuable analytical information, an understanding of their outputs must be established. Produced water reinjection has gained increasing attention in the last decade, as it can minimize negative environmental impacts by reducing oil discharge and has the potential to extend the economic life of reservoirs. To increase the amount of produced water that can be reinjected, the water must be maintained at a sufficient quality to prevent unintended formation damage. This review paper thoroughly describes different water quality issues related to suspended solids that can occur in an injection water treatment system and how the issues are often interlinked. A case study of measuring the total suspended solids concentration of seawater sampled from the Danish sector of the North Sea has been carried out to effectively quantify water quality in an injection water treatment facility. Furthermore, numerous on- and in-line techniques have been evaluated as candidates for measuring suspended solids. The last part of the paper discusses considerations regarding future microscopy analyzers based on five promising online microscopy technologies.

show abstract

Studies on the Coulter counter Part I. Investigation into the effect of orifice geometry and flow direction on the measurement of particle volume

Cited by 23 publications

References 24 publications

Modeling of colloidal transport in capillaries

Modeling of colloidal transport in capillaries

Detecting DNA Folding with Nanocapillaries

Online Quality Measurements of Total Suspended Solids for Offshore Reinjection: A Review Study

Contact Info

Product

Resources

About