Studies on the coronary circulation

Prinzmetal, Myron; Simkin, Benjamin; Bergman, Harry; Krüger, H

doi:10.1016/0002-8703(47)90090-2

Cited by 148 publications

(8 citation statements)

References 15 publications

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“…Arterioluminal vessels were not identified in the left side of the heart, in accordance with the previous findings of Maclean et al (1961) and Prinzmetal et al (1947). Moreover, the number of veins identified in the ventricles after the injection of the coronary sinus with gelatine was similar to that obtained after injection of the sinus with India ink.…”

Section: Discussionsupporting

confidence: 90%

Anatomy and clinical significance of ventricular Thebesian veins

Ansari

2001

Clin. Anat.

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Section: Discussionsupporting

confidence: 90%

Anatomy and clinical significance of ventricular Thebesian veins

Ansari

2001

Clin. Anat.

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“…Prinzmetal and Simkin addressed this question in the coronary circulation by more quantitative post-mortem studies in which they perfused human hearts with glass spheres of varying sizes. Based on their studies, they concluded that collaterals with a diameter of 70–180 m existed in the coronary circulation (729). …”

Section: Training Adaptations Within the Active Muscle: Increasedmentioning

confidence: 99%

Exercise Training and Peripheral Arterial Disease

Haas

Lloyd

Yang

et al. 2012

Comprehensive Physiology

119

108

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Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow capacity to the legs of patients. PAD leads to exercise intolerance that can progress in severity to greatly limit mobility, and in advanced cases leads to frank ischemia with pain at rest. It is estimated that 12–15 million people in the United States are diagnosed with PAD, with a much larger population that is undiagnosed. The presence of PAD predicts a 50–1500% increase in morbidity and mortality, depending on severity. Treatment of patients with PAD is limited to modification of cardiovascular disease risk factors, pharmacological intervention, surgery, and exercise therapy. Extended exercise programs that involve walking ~5 times/wk, at a significant intensity that requires frequent rest periods, are most significant. Pre-clinical studies and virtually all clinical trials demonstrate the benefits of exercise therapy, including: improved walking tolerance, modified inflammatory/hemostatic markers, enhanced vasoresponsiveness, adaptations within the limb (angiogenesis, arteriogenesis, mitochondrial synthesis) that enhance oxygen delivery and metabolic responses, potentially delayed progression of the disease, enhanced quality of life indices, and extended longevity. A synthesis is provided as to how these adaptations can develop in the context of our current state of knowledge and events known to be orchestrated by exercise. The benefits are so compelling that exercise prescription should be an essential option presented to patients with PAD in the absence of contraindications. Obviously, selecting for a life style pattern, that includes enhanced physical activity prior to the advance of PAD limitations, is the most desirable and beneficial.

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“…Anastomoses between the coronary arteries are present in the normal heart [11,12]. Furthermore, ischemic heart disease can promote collateral circulation [9].…”

Section: Discussionmentioning

confidence: 99%

Predictors and Clinical Implications of Minimal ST-Segment Elevation in Patients with ST-Segment Elevation Myocardial Infarction

et al. 2014

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Objectives: Some patients with suspected ST-segment elevation (STE) myocardial infarction (STEMI) show STE that does not fulfill the current criteria for STEMI. The purpose of this study was to investigate the characteristics and prognoses of patients with minimal STEMI. Methods: Between November 2007 and December 2011, 546 patients who underwent primary percutaneous coronary intervention (PCI) for STEMI were enrolled. Results: The minimal STE group had a higher proportion of women (30.2 vs. 21.0%, p = 0.031), better pre-PCI antegrade flow (Thrombolysis in Myocardial Infarction flow 2-3, 30.2 vs. 18.8%, p = 0.006) and better collateralization (Rentrop score 2-3, 27.4 vs. 18.1%, p = 0.024) compared to the definite STE group. Multivariate analysis showed that each of them were independent predictors for minimal STE. However, 1-year mortality of the minimal STE group did not differ from that of the definite STE group (7.1 vs. 9.3%, log-rank p = 0.315). Conclusions: Female gender, good collateral flow and good pre-PCI antegrade flow were independent predictors for minimal STE in patients with STEMI. However, minimal STE was not related to a good prognosis in patients with STEMI.

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Studies on the coronary circulation

Cited by 148 publications

References 15 publications

Anatomy and clinical significance of ventricular Thebesian veins

Anatomy and clinical significance of ventricular Thebesian veins

Exercise Training and Peripheral Arterial Disease

Predictors and Clinical Implications of Minimal ST-Segment Elevation in Patients with ST-Segment Elevation Myocardial Infarction

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