Studies on the Constituents of Lonicera Species. XVII. New Iridoid Glycosides of the Stems and Leaves of Lonicera japonica THUNB.

Biflavonoids from Lonicera japonica

“…It has been known as an anti-inflammatory agent in Korea from ancient times and is used widely for upper respiratory tract infections, diabetes mellitus and rheumatoid arthritis (Lee et al, 1998). A number of compounds such as iridoid glycosides, saponins, flavonoids and tannins have been reported from this species (Mehrotra et al, 1988;Kawai et al, 1988a,b;Machida et al, 2002;Kwak et al, 2003;Son et al, 1992Son et al, , 1994a. Although the chemical composition of L. japonica from few countries is well documented, there has been no report on the chemical composition from India.…”

Damage levels from arthropod herbivores on Lonicera maackii suggest enemy release in its introduced range

“…Resistance is the ability of a plant to reduce the preference or health of the herbivore often through mechanical defenses, such leaf toughness, thorns, or trichomes, or chemical defenses including the production of secondary defensive compounds (Ashton and Lerdau 2008;Choong 1996 1999). Much research has been conducted on secondary metabolites present in plants from the Lonicera genus, mostly in the context of their pharmaceutical benefits in herbal medicine (Chen et al 2009;Heinrich et al 2008;Machida et al 2002). Many of the identified secondary chemicals found in the Lonicera genus are known to be present in North America and therefore not novel, but a complete profile of leaf chemistry has not been done for Lonicera spp., leaving the question of whether invasive species in this genus possess chemicals novel to the native flora and fauna (Cipollini et al 2008b).…”

Triterpene Glycosides from the Stems and Leaves of <i>Lonicera japonica</i>

“…The deduced molecular formula was larger than that of 10, with the difference corresponding to C 6 Comparing the whole 13 C-NMR spectrum of 5 with that of 10, we observed the signals due to the aglycone moiety and the triglycoside residue linked to C-28 of the aglycone at almost same positions in the two compounds. However, a set of six additional signals corresponding to a terminal α-Lrhamnopyranosyl moiety appeared at δ C 101.7, 72.4, 72.5, 74.1, 69.6, and 18.7, and the signal due to C-2 of the glucopyranosyl unit attached to C-3 of the aglycone was shifted downfield by 2.0 ppm and observed at δ 77.8, suggesting that the C-2 position of the glucosyl moiety (Glc(I)) was glycosylated by the additional L-rhamnosyl unit (Rha(I)).…”

“…The stems and leaves of L. japonica have been chemically investigated, and iridoid glycosides and a number of triterpene glycosides have been isolated; some of these compounds may contribute to the medicinal effects of this crude drug. [2][3][4][5][6] As part of our continuing investigation of triterpene glycosides from medicinal plants, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] we conducted phytochemical screening of the stems and leaves of L. japonica and isolated five new triterpene glycosides, together with five known ones. Here we report the structures of these compounds, based on extensive spectroscopic analysis, including two-dimensional (2D)-NMR experiments, and the results of hydrolysis.…”