Studies on the Concentration of Streptomycin in the Treatment of Tuberculosis of the Joints

The penetration of drugs into the lesions of spinal tuberculosis

“…This type of study is difficult because of the large number of variables present, and other workers have produced results which have varied from patient to [2,3,4,6,7]. There were similar variations in our cases and, therefore the range of concentration is given in Table 1 and, as the numbers were small, the nonparametric statistical Wilcoxon test was used.…”

“…The ability of antituberculous drugs to reach the site of osteoarticular lesions, when given adequate concentration, has been demonstrated by several workers in animal experiments and in humans [1,2,3,5,7]. There is, however, very little information available on the reassessment of drug concentration at the site of lesions after a period of chemotherapy [6].…”

Penetration of Antitubercular Drugs in Clinical Osteoarticular Tubercular Lesions

“…Earlier workers (Fellander et al 1952, Katayama et al 1954, Friedman & Kapur 1973) who tried to determine the concentration of streptomycin in tuberculous material in human skeletal tuberculous lesions observed a wide variation in their results from patient to patient. Similar variations were observed in our study and that is why the data have been statistically analysed for clinical application and the range of concentrations has been mentioned.…”