STUDIES ON THE CHEMICAL CONSTITUTION OF EGYPTIAN<i>NIGELLA SATIVA</i>L. OIL

Gad, A. M.; El–Dakhakhny, M.; Hassan, Mohamed M.

doi:10.1055/s-0028-1100226

Cited by 42 publications

(23 citation statements)

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“…The exact mechanism of action of N. sativa is not known, however, it has been proved that volatile oil of N. sativa has two main constituents i.e. nigellone and thymoquinone which play a key role in heart disease prevention [67][68][69]. According to Feldman [70] antioxidants (e.g., vitamins E and C) may lessen the risk CVD by decreasing oxidized LDL, which is more atherogenic.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Al-Logmani¹,

Zari²

2011

JDM

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The long-term effects of Nigella sativa L. oil on some physiological parameters were investigated in normal and streptozotocin (STZ)-induced diabetic male Wistar rats. STZ-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein (LDL-cholesterol), uric acid, urea, creatinine, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) while high density lipoprotein (HDL-cholesterol) and total protein levels were significantly decreased compared to normal rats. Administration of black seed oil to diabetic rats resulted in a significant decrease in blood glucose, triglycerides, cholesterol, LDL-cholesterol ALT, AST and uric acid while HDL-cholesterol level was markedly increased compared to untreated diabetic rats after seven weeks of treatment. The results of this study indicate that the diet containing the oil of N. sativa improves the examined physiological parameters in STZ-induced diabetic rats especially when it is used for a longer period.

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Section: Discussionmentioning

confidence: 99%

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Al-Logmani¹,

Zari²

2011

JDM

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“…nigellone and thymoquinone which play a key role in heart disease prevention. [21][22][23] In conclusion, the present study show that there is a significant (P<0.01) decrease in TC, LDL, and TG, and significant increase of HDL by Nigella sativa.…”

Section: Effect Of Kalonji (Nigella Sativa)mentioning

confidence: 92%

Effects of Nigella sativa (Kalonji) and Honey on Lipid Profile of Hyper lipidemic Smokers

Bhatti¹,

Inayat²,

Uzair³

et al. 2016

IJPER

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Background:Hyper lipidemia refers to the excess of lipids in the blood of patients. The present study was carried out to investigate the effect of Nigella sativa (kalonji) and honey as compared with Atorvastatin on the lipid profile of hyper lipidemia patients with habit of smoking. Methodology: Purposes, 60 patients (3 groups of 20) of 35-65 years were selected. These patients were treated with 1 g of Nigella sativa (kalonji) seed, one tablespoon of honey, and Atorvastatin 10 mg daily in the morning at fasting for a period of 30 days. Results: The results obtained showed that Nigella sativa (kalonji), honey as well as Atorvastatin lowered significantly the levels of total cholesterol (TC), low density lipoproteins (LDL) and triglycerides (TGs) after 30 days of treatment. On the other hand, all the treatments increased HDL levels significantly after 30 days treatments were non-significant on TC and LDL levels of smokers. But after 30 days of treatment, Atorvastatin was significantly more effective than honey and Nigella sativa (kalonji). Honey reduced TGs level of smokers significantly over Nigella sativa (kalonji) and Atorvastatin. Conclusion: It can be concluded that both Nigella sativa (kalonji) and honey were as effective as Atorvastatin or more effective in some cases in reducing TC, LDL and TGs of hyper lipidemic smokers significantly while HDL levels were increased significantly.

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“…Many reports 6,[16][17][18][19] demonstrated that the main components of essential oil extracted from N. sativa (L.) seeds are p-cymene (37.3％), thymoquinone (13.7％), carvone (0.9％), thymol (0.33％), and carvacrol (11.77％). Thoseˆndings conˆrmed that most bioactive molecules present in essential oil are phenols.…”

Section: Resultsmentioning

confidence: 99%

Effects of Essential Oil Extracted from <i>Nigella sativa</i> (L.) Seeds and Its Main Components on Human Neutrophil Elastase Activity

Kacem

Meraïhi

2006

YAKUGAKU ZASSHI

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The eŠects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase (HNE) activity were investigated. Essential oil was extracted from N. sativa (L.) seeds using hydrodistillation. The yield was equal to 0.4％. Inhibition of HNE activity by essential oil was found to be dose dependent. The highest inhibitory concentration (HIC) of essential oil which caused total inhibition of HNE activity was 5.8 mg/ml. Microassays carried out to evaluate the inhibitory eŠect of major components of essential oil on HNE activity revealed that carvacrol (5-isopropyl-2-methylphenol) showed marked HNE inhibitory activity with a very low IC 50 value (12 mM). Based on these results, the inhibitory eŠects of essential oil on HNE activity are due to the presence of bioactive molecules, mainly carvacrol this compound is an inhibitor of HNE and could be considered as a natural antielastase agent and possible candidate for phytotherapy in the treatment of injuries that appear in some pathologic cases such as chronic obstructive pulmonary disease and emphysema.

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STUDIES ON THE CHEMICAL CONSTITUTION OF EGYPTIANNIGELLA SATIVAL. OIL

Abstract: Nigella sutiva L. is an annual of the Ranztnculaceae herbaceous plant growing in countries bordering on the Mediterranean Sea. Its seeds are reputated and used by the common people for many medicinal purposes.

Cited by 42 publications

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Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Long-term effects of Nigella sativa L. oil on some physiological parameters in normal and streptozotocin-induced diabetic rats

Effects of Nigella sativa (Kalonji) and Honey on Lipid Profile of Hyper lipidemic Smokers

Effects of Essential Oil Extracted from <i>Nigella sativa</i> (L.) Seeds and Its Main Components on Human Neutrophil Elastase Activity

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