Studies on the Chemical Constituents of Nardostachys jatamansi DC (Valerianaceae).

Chatterjee, A.; Basak, Bidyut; Datta, U.; Banerji, Julie; Neuman, A.; Prangé, T.

doi:10.1002/chin.200525180

Cited by 16 publications

(17 citation statements)

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“…Its structure was confirmed by 1 H‐ and 13 C‐NMR and HR mass analysis. The NMR data were found to exactly match with the reported values of nardin (Chatterjee et al ., 2005; Rao et al ., 2008). The accurate mass calculated for nardin, [M − H] ‐ C 15 H 21 O 2 was 233.1542 and the measured m / z value was 233.1548 (2.5 ppm; Fig.…”

Section: Resultsmentioning

confidence: 99%

A rapid and highly sensitive UPLC–QTOF MS method for quantitative evaluation of Nardostachys jatamansi using Nardin as the marker

Mallavadhani

Panigrahi

2010

Biomedical Chromatography

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Nardostachys jatamansi DC. is a highly reputed Medhya and Nootropic (Learning and Memory) Ayurvedic medicinal plant. Its use as herbal medicine singly and as an ingredient of multi-herbal formulations is fast increasing. In order to authenticate and evaluate it quantitatively, its standardization is highly warranted with respect to a reliable marker. In this connection a rapid and highly sensitive UPLC-QTOF MS method has been developed. The analysis was carried out on an Acquity BEH C(18) column with gradient elution of methanol-water and 3 mm ammonium acetate using QTOF mass detector in negative ionization mode. The method was validated over a concentration range of 9.76-156.25 ng/mL nardin. The calibration curve is linear with the correlation coefficient (r) and coefficient of determination (R(2)) were 0.9997 and 0.9995 respectively. The LOD and LOQ were 3.050 and 9.277 ng/mL respectively. The recovery of nardin in the range 96.36-111.13% achieved from spiked samples was consistent and reproducible. The inter-day and intra-day assay precision of the analytes over the entire concentration range was less than 5%. The developed method required only 4 min for chromatography to authenticate and quantify the marker, viz. nardin in N. jatamansi samples, in addition to the sample preparation time.

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Section: Resultsmentioning

confidence: 99%

A rapid and highly sensitive UPLC–QTOF MS method for quantitative evaluation of Nardostachys jatamansi using Nardin as the marker

Mallavadhani

Panigrahi

2010

Biomedical Chromatography

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“…Kanshone B (17) differs from 15 only by the presence of an extra oxygen atom that revealed 16 has a hydroxyl group at C-2. Kanshone A (18) has the same carbon framework and stereochemistry as that of 1 and bears (Bagchi, Oshima, & Hikino, 1991;Chatterjee et al, 2005) Roots and rhizomes powder Epilepsy, stress, anxiety, fever, hysteria, mental weakness, menopausal symptoms, intestinal colic, and syncope External application of oil Inflammation of the uterus, eye compounds, and hair fall Hot infusion Melancholic depression Roots powder Epilepsy, heart palpitation, hysteria, and cholera (Dweck, 1996;Rai et al, 2000) External application of roots powder paste Boils, diseases of the eyes, and itch Infusion of roots Flatulence, jaundice, spasmodic hysterical affections, nervous headache, palpitation of the heart, and leprosy (Kapoor, 2000) 2. Islamic Herb powder, decoction, and infusion Cardiotonic, diuretic, hepatic tonic, and analgesic (Ali et al, 2000) 3.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Epilepsy is the condition of recurrent spontaneous seizures arising from abnormal electrical activity within the brain (McCormick & Contreras, 2001). N. chinensis is widely used traditionally for the treatment of seizures, nervous headaches, insomnia, epilepsy, and other convulsive ailments (Chatterjee et al, 2005;Dweck, 1996;Houghton, 1999;Kapoor, 2000). For validation of traditional use of N. chinensis in epilepsy treatment, various animal studies have been conducted.…”

Section: Anticonvulsant Activitymentioning

confidence: 99%

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Rehman

Ahmad

2019

Phytotherapy Research

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Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its traditional uses. This review aims to summarize reported traditional uses, phytochemistry, and pharmacological potential of N. chinensis while identifying potential areas of further research of plant. The review comprises literature pertaining to the pharmacological potential and phytochemistry of N. chinensis using worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, Pub Med, Scopus, Springer, Wiley online library). Moreover, data from ethno botanical text books available in library and electronic search were also included. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name. Different pharmacological experiments in many in vitro and in vivo models have proved the potential of N. chinensis, namely, antiinflammatory, anticonvulsant, antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, aldose reductase inhibition, and antioxidant activities. The plant contains sesquiterpenenes of various varieties including aristolane, guaiane, and nardosinane types. Moreover, it also contains coumarins, phenols, lignans, neolignans, and glycosides. Reported activities suggested that there may be pharmacological potential for developing N. chinensis as a drug for infections, hypertension, cardiac diseases, Alzheimer's disease, insomnia, epilepsy, cancer, gastric, and liver diseases. More toxicological studies should be performed that will aid the progress to clinical trial studies of N. chinensis. Abbreviations: 2K1C, two-kidney one-clip; 5-HT, 5-hydroxytryptamine; ABTS, 2,2′-azino-bis; AChEI, acetylcholinesterase; BChE, butyrylcholinesterase; Bcl-2, B-cell lymphoma 2; CDK, cyclindependent kinase; dbcAMP, dibutyryl cyclic adenosine mono phosphate; Dct, dopachrometautomerase; DPPH, 2,2, diphenyly 1-picryl hydrazyl; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; EV, estradiol valerate; FRAP, ferric reducing antioxidant power; GAP-43, growth associated protein 43; ICAM-1, intracellular cell adhesion molecule 1; IP-10, interferon gamma-induced protein 10; I-TAC, interferon-inducible T-cell alpha chemo attractant; IVSd, interventricular septal diameter at end-diastole; IVSs, interventricular septal diameter at end-systole; LDL, low-density lipoprotein; LPS, lipopolysaccharide; LTA, lipoteichoic acid; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal diameter at end-diastole; LVIDs, left ventricular internal diameter at end-systole; LVPWd, left ventricular posterior wall at end-diastole; LVPWs, left ventricular posteriorwall at end-systole; LVW/BW, left vent...

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“…Volatile essential oil, resins, sugar, starch, bitter extractive matter, gum, ketone, sesqueterpin ketone, spirojatamol etc 4,5 . Other sesquiterpenes include nardin, nardal, jatamnsic acid, b-maline and patchouli alcohol 6 .…”

Section: Chemical Constituentsmentioning

confidence: 99%

Medicinal Properties of Nardostachys jatamansi (A Review)

Sahu¹,

Dhongade²,

Pandey³

et al. 2016

Orient. J. Chem

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Nardostachys jatamansi DC. is an endangered, primitive and therapeutic herbal agent belonging to family Valerianaceae. The rhizomes of this hairy, perennial, dwarf and herbaceous plant are used for therapeutic effect in ayurvedic and unani system of medicine. Nardostachys jatamansi has been reported to have many therapeutic activities like antifungal, antimicrobial, antioxidant, hepatoprotective and cardio protective properties. It is used in the treatment of insomnia and CNS disorders. The vasodilator, bronchodilator, spasmolytic and platelet aggregation inhibition activities of the plant have also been reported. Jatamansone, nardostachone and actinidine are the major secondary metabolites present in the plant. This review article is summary of the potential benefits of this medicinal plant as reported in literature. The review also highlights the need for the use of this plant in Ayurvedic system of medicine and future prospects for further research.

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Studies on the Chemical Constituents of Nardostachys jatamansi DC (Valerianaceae).

Cited by 16 publications

References 0 publications

A rapid and highly sensitive UPLC–QTOF MS method for quantitative evaluation of Nardostachys jatamansi using Nardin as the marker

A rapid and highly sensitive UPLC–QTOF MS method for quantitative evaluation of Nardostachys jatamansi using Nardin as the marker

Nardostachys chinensis Batalin: A review of traditional uses, phytochemistry, and pharmacology

Medicinal Properties of Nardostachys jatamansi (A Review)

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