Renal calculus is a hard mass. It is formed from the crystals that aggregate onthe inner surfaces of the kidney. Small crystals flow to the urinary tract and pass out of the bodyspontaneously along with urine without being noticed. Objectives: The purpose of the presentstudy is to find the type; age and gender related prevalence of the renal calculus disease inSouthern Punjab Pakistan. Study design: The study design is retrospective. Period: Two yearfrom June 2009 to June 2011. Materials and Methods: In this work, 1176 samples of renalcalculi from both male and female patients of the southern Punjab, Pakistan, were collected.Semiquantitative analysis of the renal calculi was carried out using Merckogonost Reagent Kit.Results: Highest prevalence of the renal calculus disease was in the age group 40-49 in malesand in the age group 30-39 in females. The disease was more common in males than females.Calcium oxalate was the predominant renal stone.