Studies on the changes in lipid peroxidation and antioxidants in fishes exposed to Hydrogen Sulfide

Abstract

In the present aquarium study, Oreochromis mossambicus Peters were exposed to two different concentrations of hydrogen sulfide (H2S) (4.9 and 6.6 mg/l), and the changes in lipid peroxidation (LP) products and antioxidants in test fishes were determined in time intervals of 12, 24, 48, 72, and 96 hours. The results showed that with respect to the H2S concentration and duration of exposure, alterations were observed in the concentration of LP products and antioxidants in the various organs of the test fishes. Malondialdehyde (MDA) content increased in the liver, gill, kidney, and brain on exposure to H2S up to 48 hours, and then the MDA content showed steady value up to 98 hours experimental period. Brain and kidney of fishes showed the maximum increase in concentration of reduced glutathione (GSH) on H2S treatment. The gradual decrease in concentration of GSH in the tissues of H2 S-exposed fishes after 48 to 96 hours compared with the control shows the loss of adaptive mechanisms and the oxidation of GSH to glutathione disulphide (GSSG). Slight increase in the activity of GSH-S-transferase and decrease in activity of GSH peroxidase demonstrated the incapability of the vital organs in neutralizing the peroxides generated in the oxidative stress condition.

Heavy metals, parasitologic and oxidative stress biomarker investigations in Heterotis niloticus from Lekki Lagoon, Lagos, Nigeria

“…In this study, the liver and intestines of fish infected with parasites showed increased level of MDA compared with the unparasitized fish, even though the increases were not significant. This may be attributed to the elevated oxidation of molecular oxygen (O 2 ) to produce superoxide radicals, an indication of the important roles of the fish tissues, particularly the liver in the detoxification process [ 78 ]. Increased MDA levels also be as a result of impairment in antioxidant enzymes due to enhanced ROS formation.…”

“…Results in the present study indicate high GSH activities in host tissues of parasitized fish, suggesting toxicity as a result of parasitic infection or possibly due to organic pollution as reported by Wilhelm-Filho et al [ 82 ]. Increased GSH level could be an adaptive mechanism to slight oxidative stress [ 78 ]. Furthermore, alterations in the activities of GSH in the tissues of fish has been suggested to be as a result of organ-specific responses [ [83] , [84] , [85] ].…”

Hydrogen Sulfide Gas Exposure Induces Necroptosis and Promotes Inflammation through the MAPK/NF-κB Pathway in Broiler Spleen

“…Among workers with long exposure to H 2 S, the expression level of proinflammatory interleukin- (IL-) 8 was increased significantly [6], suggesting the immune injury of H 2 S exposure. Sreejai and Jaya reported that H 2 S exposure induced oxidative stress and weakened antioxidant ability in fishes [7]. In addition, H 2 S is one of the harmful gases that the poultry industry pays close attention to; it has been reported that H 2 S in chicken houses significantly reduced meat quality and the laying rate of broilers [8].…”

Evaluation of Oxidative Stress Biomarkers and Atherogenic Indices in Adult Wistar Rats Exposed to Pyrethroid Insecticides

“…The disparities might be due to route of exposure (Inhalation), which has low systemic toxicity [31] and perhaps exposure to pyrethroid pesticides could affect lipid metabolism, and it also indicates that lipid peroxidation is occurring even though the effect might be low. Total cholesterol is a major constituent of cell membranes, steroids and signaling molecules and these molecules are easily damaged by free radicals produced due to exposure to pyrethroid pesticides [40]. The decreased in plasma SOD and CAT activity might be due to increased H 2 O 2 production in exposed groups.…”