Studies on the Biologic Characterization of Human Gonadotropins. Vii. Urinary Gonadotropins of Men, Postmenopausal Women and Eunuchs*

Albert, A.; Derner, Ione; Leiferman, John; Stellmacher, Virginia; Barnum, Jerusha

doi:10.1210/jcem-21-7-839

Cited by 17 publications

(8 citation statements)

References 3 publications

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“…Our results for FSH and LH in adult males agree well with other published values on male urine pools (5,12,13) when the reported values have been converted to 2nd IRP (11).…”

Section: Discussionsupporting

confidence: 91%

“…There are no data with which to compare our (12,13,(15)(16)(17)(18)(19) found that FSH/LH ratios in urine pools from men and postmenopausal women were similar, others (20-21) report differences. Eunuchs, however, have uniformly been found to have urinary FSH/LH ratios 2.0 to 6 times higher than either normal men or postmenopausal women (13,16,17).…”

Section: Discussionmentioning

confidence: 56%

“…Eunuchs, however, have uniformly been found to have urinary FSH/LH ratios 2.0 to 6 times higher than either normal men or postmenopausal women (13,16,17). Although prepubertal children excrete smaller amounts of gonadotropin than eunuchs they exhibit the same high FSH/ LH ratio.…”

Section: Discussionmentioning

confidence: 99%

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Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the Urine of Prepubertal Children*

Rifkind¹,

Kulin²,

Ross³

1967

J. Clin. Invest.

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Abstract. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) have been measured by specific bioassays in pooled urine samples from prepubertal children, aged 2-6 yr, and from male adults. For children the mean urinary excretion of FSH was 2.2 U 2nd International Reference Preparation (2nd IRP) per liter and the mean -urinary excretion of LH was 0.44 U 2nd IRP per liter. For adults the mean FSH excretion was 5.6 U 2nd IRP per liter and the mean LH excretion was 4.7 U 2nd IRP per liter. Our data show a 2.5-fold increase of FSH, a 10.7-fold increase of LH, and a consequent decrease in the FSH: LH ratio from 5 to 1 between childhood and adulthood. FSH and LH in urine from three patients with gonadal abnormalities have also been studied. The results from normal children, adults, and abnormal patients form a spectrum and reveal that sexual maturity is accompanied by a marked increase in the excretion of LH with relatively smaller increases in FSH.

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“…Our results for FSH and LH in adult males agree well with other published values on male urine pools (5,12,13) when the reported values have been converted to 2nd IRP (11).…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 56%

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Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the Urine of Prepubertal Children*

Rifkind¹,

Kulin²,

Ross³

1967

J. Clin. Invest.

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“…Studies with the urine of human castrates show that FSH activity increases to a greater extent than LH activity (Albert, Derner, Leiferman, Stellmacher & Barnum, 1961 ;Rosemberg & Engel, 1962). All the sheep in the present study had been castrated for several years and therefore their urines could be expected to contain considerable FSH activity.…”

Section: Discussionmentioning

confidence: 60%

The Urinary Excretion of Gonadotrophins by Sheep: Extraction Procedure and Day-to-Day Fluctuation in Excretion by Male and Female Castrated Sheep

Symington¹

1964

Journal of Endocrinology

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The application of Johnsen's tannic acid method to the extraction of gonadotrophins from ovine urine was studied using the urine of castrated sheep.Slight modification of the original method increased the efficiency of extraction. Rate of recovery was measured at several levels of added pituitary and urinary gonadotrophins and was similar to recovery rates reported for human urines (30\p=n-\81 %). Reproducibility of the extraction procedure was excellent. Further purification of the final ethanol precipitate without loss in potency was effected by chromatography using diethylaminoethyl cellulose. The daily excretion of total gonadotrophic activity, follicle stimulating hormone and luteinizing hormone by two male and one female castrated sheep was estimated for four periods each of 3 weeks. In all instances excretory levels fluctuated considerably and randomly. Levels of excretion of all types of gonadotrophic activity were much lower than in man.

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“…Der nicht dialysierte Extrakt würde in diesem Fall vom Ver suchstier meist nicht vertragen. Der Urin wird wiederum schwach angesäuert, fil triert und mit wenig NaCl und 4 [3,6,7,16,17,24].…”

Section: B) Alkoholfällung Mit Dialyseunclassified

Die Bestimmung hypophysärer Gonadotropine im Urin

Pj¹

1963

Gynecol Obstet Invest

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Studies on the Biologic Characterization of Human Gonadotropins. Vii. Urinary Gonadotropins of Men, Postmenopausal Women and Eunuchs*

Cited by 17 publications

References 3 publications

Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the Urine of Prepubertal Children*

Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) in the Urine of Prepubertal Children*

The Urinary Excretion of Gonadotrophins by Sheep: Extraction Procedure and Day-to-Day Fluctuation in Excretion by Male and Female Castrated Sheep

Die Bestimmung hypophysärer Gonadotropine im Urin

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