Studies on the antigenicity of bone. I. Freeze-dried and deep-frozen bone allografts in rabbits

Ge, Friedlaender; Dm, Strong; Kw, Sell

doi:10.2106/00004623-197658060-00018

Cited by 218 publications

(66 citation statements)

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“…Each author and contributor of patient material certifies that his or her institution has approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent was obtained for participating in the study. [9,10]. The most common causes for graft failure are limited incorporation of the allograft into host tissue, fractures, infections, or unopposed resorption.…”

Section: Introductionmentioning

confidence: 99%

HLA Sensitization and Allograft Bone Graft Incorporation

Ward

Gautreaux

Lippert

et al. 2008

Clin Orthop Relat Res

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Achieving union between host bone and massive structural allografts can be difficult. Donor and recipient human leukocyte antigen (HLA) mismatches and recipient antibody response to donor HLA antigens might affect union. In a prospective multiinstitutional study, we enrolled a consecutive series of patients receiving cortexreplacing, massive structural bone allografts to determine the rate of donor-specific HLA antibody sensitization and to investigate the potential effect of such HLA alloantibody sensitization on allograft incorporation. HLA typing of patients and donors was determined by molecular typing methods. Donor-specific HLA sensitization occurred in 57% of the patients but had no demonstrable effect on graft incorporation or union. The type of host-allograft junction did have a major effect on graft incorporation. Cortical-tocortical allograft-to-host junctions healed more slowly (mean, 542 days) than corticocancellous to corticocancellous allograft-to-host junctions (mean, 243 days). Although HLA sensitization does not appear to delay structural allograft bone incorporation, further followup is required to determine if there is an association between HLA sensitization and long-term graft survival. Based on these preliminary data, measures to further minimize or modulate HLA sensitization or response are not indicated at present for the purposes of improving structural bone allograft union.

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Section: Introductionmentioning

confidence: 99%

HLA Sensitization and Allograft Bone Graft Incorporation

Ward

Gautreaux

Lippert

et al. 2008

Clin Orthop Relat Res

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“…Also, the freeze drying at -196°C destroys the antigenicity of the DFDBA [14][15][16][17]. . Porous HA is an abundantly available non toxic material [18] that is bioactive and allows new bone to be formed directly on its surface without any intervening layer of fibrous tissue [19].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Evaluation of Decalcified Freeze Dried Bone Allograft, Hydroxyapatite and Their Combination in Osseous Defects of the Jaws

Mishra

Singh

Mohammad

et al. 2010

J. Maxillofac. Oral Surg.

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Objectives To evaluate decalcified freeze dried allograft or hydroxyapatite and a combination of both as bone autograft substitutes in the healing of osseous jaw defects. Materials and Methods 24 patients participated in the study which involved the filling of osseous defects in the maxilla/mandible with decalcified freeze dried bone allograft (DFDBA) or hydroxyapatite (HA) or a combined graft composed of these two in equal proportions. Results Bone formation occurred as early as 4 weeks in the DFDBA and combination groups and 12 weeks in the HA group which was verified by radiographs, Dentascans (DentaScanÒ Software Program, General Electric, USA) and bone scintigraphy. Conclusion Both these materials can be used as bone graft substitutes in smaller defects although their suitability in large defects is yet to be studied.

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“…He felt that protracted sequestration and slow resorption mitigated against the use of organic bone. Scopp et al (1966), 9 used Boplant bovine bone and reported pocket depth reduction at 6 months. Older (1967) 10 reported good results by measuring by probing depth reduction and increasing radiographic density.…”

Section: Historical Perspectivementioning

confidence: 99%