“…Metabolites of certain nematodes have been shown to be immunogenic (Soulsby, 1958;Thorson, 1956;Ewert and Olson, 1960), to contain a variety of antigens , to have various enzymes (review: Soulsby, 1958), to induce shock in nematode-infected animals (Sprent, 1951 ) and in gut segments from nematodeinfected or metabolite-injected animals Olson, 1961, 1962), but in spite of some chemical characterization (review: Weinstein, 1959), little is known of metabolites in terms of allergenicity. Extracts of adult or larval nematodes have been shown to contain a variety of antigens (Wodehouse, 1956;Kagan, 1957;Labzoffsky et al, 1959; al., Tanner and Gregory, 1961;Huntley and Moreland, 1963). some of which induce anaphylaxsis in nematode-infected guinea pigs (Oliver-Gonzalez, 1946;Sprent, 1951;.…”