Studies on the antibacterial activity of Khaya senegalensis [(Desr.) A. Juss)] stem bark extract on Salmonella enterica subsp. enterica serovar Typhi [(ex Kauffmann and Edwards) Le Minor and Popoff]

Ugoh, Sylvanus Chukwudi; Agarry, S. E.; Garba, S.

doi:10.12980/apjtb.4.2014c636

Cited by 15 publications

(12 citation statements)

References 10 publications

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“…There is no significant difference with the results obtained by Abdallah et al, 17 who found a MIC of 50mg/ml for the aqueous extract and 25mg/ml for the ethanolic extract of the trunk bark of Khaya Senegalensis on a strain of the genus Salmonella. These values are lower than those obtained by Ugoh et al 28 who also conducted antimicrobial tests of aqueous and ethanolic extracts of the trunk bark of Khaya senegalensis and found a MIC of 200mg/ml for both extracts on a strain of Salmonella typhi. The differences observed with the other authors could be explained by several factors, including the nature of the solvents of extractions and the antimicrobial tests used.…”

Section: Resultscontrasting

confidence: 70%

In vitro anti-radical and anti-salmonella activities of sarcocephalus latifolius, lannea barteri, uvaria chamae, parkia biglobosa and khaya senegalensis

Katawa¹,

Bomboma²,

Komi-Koukoura³

et al. 2018

JAPLR

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Section: Resultscontrasting

confidence: 70%

In vitro anti-radical and anti-salmonella activities of sarcocephalus latifolius, lannea barteri, uvaria chamae, parkia biglobosa and khaya senegalensis

Katawa¹,

Bomboma²,

Komi-Koukoura³

et al. 2018

JAPLR

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“…malaria [ 87 ] Antibacterial activity against S. enterica subsp. Enterica serovar typhi (50% ethanolic leaf extract) [ 171 ], in vivo hypoglycemic activity (Ethyl acetate extract) [ 172 ], hepatoprotective effects [ 173 ], antioxidant activity (Ethanolic extract) [ 174 ] in vitro (Agar well diffusion method) [ 171 ], in vivo (rats) [ 172 ], in vivo (rats) [ 173 ], in vitro (DPPH radical scavenging assay, deoxyribose assay, Nitric oxide radical scavenging assay) [ 174 ] Orally administered ethanol stem bark extract in rats at a dose of 2 mg/kg for 18 days was reported to induce the synthesis of liver enzymes [ 175 ]. The subchronic administration of the aqueous stem bark extract to rats was reported to affect the cellular integrity of vital organs of the body [ 176 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

et al. 2020

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Background: Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. The preservation of this knowledge may facilitate scientific inquiry into promising new therapeutic molecules. Methods: Semi-structured questionnaires were used to collect the sociodemographic information of 30 herbalists in Kisumu East Sub County. The local names of medicinal plants used in managing illnesses of the respiratory system, their habit, active parts, indications, methods of preparation, routes of administration, scientific identity, and conservation status were also recorded. Other reported traditional uses, pharmacological activities, and toxicological data were identified via a literature search. Results: Most herbalists were female (86.7%), aged between 61 and 70 years (43.3%) with no formal education (56.7%), and had 21-30 years of practice (30%). 44 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae plant families were predominant, leaves were frequently used (33%), and trees were the most common habit (44.4%). Most plants were collected in the wild (79.2%), preparation was mainly by decoction (68.8%), and the administration was mainly orally. The main indication was cough and 79.5% of all documented plant species had previously been reported to have a pharmacological activity relevant to the mitigation of respiratory illnesses. Toxicological data was available for 84.1% of the plant species identified. Conclusions: The predominant use of roots, root barks, and root tubers by herbalists in Kisumu East Sub County threatens to negatively impact the ecological survival of some plant species. The preservation of herbalists' knowledge of medicinal plants in the study area is a pressing concern considering their advanced age and little formal education. There is a need to conserve some of the medicinal plants documented in this study. The medicinal claims made by herbalists also warrant scientific scrutiny.

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“…Malaria [99,109], constipation, jaundice [65], aphrodisiac, general wellbeing [14], sexually transmitted Infections [67] The acetone stem bark extract showed antibacterial activity against Proteus mirabilis [64], the aqueous pulp extract showed antibacterial activity against S. aureus, E. coli and P. aureginosa [110], tannins, phlobatamins, alkaloids, saponins, and sesquiterpenes were found present [64] Tylosema fassoglense (Kotschy ex Schweinf.) Torre & Hillc.…”

Section: Graymentioning

confidence: 99%

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

Mailu

Nguta

Mbaria

et al. 2020

Preprint

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Background Respiratory diseases cause many deaths in children under 5 years of age particularly in Africa. The efficacy of current treatment differs among respiratory diseases and adverse effects may depend on dosage, duration of treatment, and the type of drug. Poor access to healthcare in rural areas makes many people in such communities to rely on traditional medicine. Most knowledge on traditional medicine makes use of indigenous remedies which are often undocumented and are at risk of being lost. Ethnobotanical data on medicinal plants used in managing diseases of the respiratory system may facilitate the search for new pharmaceutical agents. Methods Semi-structured questionnaires were used to collect information from 30 traditional medicine practitioners in Kisumu East Sub County. The sociodemographic characteristics of the informants, the local names of the plants used, their habit, active parts, indications, and methods of preparation, as well as routes of administration, scientific identity, and conservation status were recorded. A literature search was conducted via PubMed, Google Scholar, and Research Gate to identify other reported activities of the plants. Results Most practitioners were female (86.7%), were aged between 61 and 70 years (43.3%), had no formal education (56.7%), and had 21-30 years of practice (30%). A total of 45 plant species, belonging to 43 genera and 28 families were identified. Leguminosae and Rutaceae were the most dominant plant families, leaves were the most frequently used (33%), and trees were the most common habit (44.4%). Cough was the most common indication, decoction was the most common method of administration (68.8%), most preparations were taken orally, and most plants were collected in the wild (79.2%). Literature search established that at least 42/45 plant species had pharmacological activities. Conclusions Many plant species reported in this study have similar traditional uses in other communities. One plant; Keetia gueinzii (Sond.) Bridson was reported for the first time in the management of asthma, pneumonia, and cough. Documentation and preservation of ethno medicinal knowledge in the study area is of prime concern as most practitioners are advanced in age with little formal education. Plans to conserve some of the medicinal plants documented here should be initiated. Scientific validation of the traditional claims made is also needed.

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Studies on the antibacterial activity of Khaya senegalensis [(Desr.) A. Juss)] stem bark extract on Salmonella enterica subsp. enterica serovar Typhi [(ex Kauffmann and Edwards) Le Minor and Popoff]

Abstract: The antibacterial properties of K. senegalensis stem bark extract can be harnessed for the production of new antibiotics or the enhancement of already existing antibiotics.

Cited by 15 publications

References 10 publications

In vitro anti-radical and anti-salmonella activities of sarcocephalus latifolius, lannea barteri, uvaria chamae, parkia biglobosa and khaya senegalensis

In vitro anti-radical and anti-salmonella activities of sarcocephalus latifolius, lannea barteri, uvaria chamae, parkia biglobosa and khaya senegalensis

Medicinal plants used in managing diseases of the respiratory system among the Luo community: an appraisal of Kisumu East Sub-County, Kenya

Medicinal Plants Used In Managing Diseases Of The Respiratory System Among The Luo Community: An Appraisal Of Kisumu East Sub-County, Kenya

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