Abstract:The binding of formaldehyde with tetanus toxin under mild detoxificatIOn conditions (0 �1M phosphate buffer, pH 7� 0, O� 005-0� 06M HCHO, 20-37�C) has been studied quantitatively by using [14C]formaldehyde. When detoxification was followed with time (0� 005M HCHO, 37�C) the toxin showed a characteristic immediate drop in lethality (~80%), followed by a slower detoxification, whereas the combination of the HCHO was a more gradual process. When a fixed time period was used (5 days, 20 and 37�C) at least O' 02M H… Show more
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