Studies on Synthesis of Novel Pyrido[2,3‐d] pyrimidine Derivatives and Their Anticancer Activity

Abstract

A series of novel pyrido[2,3-d]pyrimidine derivatives 7 were prepared starting from 2-amino nicotinonitrile 3 via Grignards reaction followed by cyclization and nucleophilic substitution. All the products 7 were screened against four human cancer cell lines . Compounds 7b, 7e, 7m, and 7o that showed good activity against all the cell lines have been identified.

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective

“…Compound 157 was found to be the most effective of these derivatives since it had an IC 50 value of 19 µg/mL against B16F10 cell line. Further, 5-Fluorouracil was used as a reference drug which showed IC 50 value of 4.03, 9.82, 0.87 and 0.54 µg/mL against Colo205, B16F10, U937 and THP-1 cell lines respectively [ 271 ]. Behalo et al (2017) produced new series of pyrido[2,3-d] pyrimidine derivatives and tested their anticancer activity against two cell lines: PC-3 and MCF-7.…”

One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

“…[13] moiety due to their potential and applications in electrochromic, solvatochromic, optical, photochromic, [14] anti-corrosive, [15] chemosensor, [16] optoelectronics or organic light-emitting diodes, [17] and photoproduct of DNA. [18] In therapeutic industry, pyrimidine derivatives have also been reported to have a broad spectrum of biological properties, that is, anticancer, [19][20][21][22][23][24][25][26][27][28][29][30] antihistamine, [31,32] antinociceptive, [33] antilipase, [34] antifilarial, [35] antiparasitic, [36] antioxidant, [37,38] antituberculosis, [39,40] antihypertensive, [41] antimicrobial, [42][43][44][45][46][47] anticonvulsant, [48,49] antiallergic, [50,51] antipyretic, [52] anti-inflammatory. [53,54] antifungal, [55,56] antiviral, [57]…”