Studies on synthesis and influence of sterically driven Ni(II)-terpyridine (NNN) complexes on BSA/DNA binding and anticancer activity

Panicker, Rakesh R.; Sivaramakrishna, Akella

doi:10.1016/j.jinorgbio.2024.112553

Journal of Inorganic Biochemistry

2024

DOI: 10.1016/j.jinorgbio.2024.112553

|View full text |Cite

Studies on synthesis and influence of sterically driven Ni(II)-terpyridine (NNN) complexes on BSA/DNA binding and anticancer activity

Rakesh R. Panicker,

Akella Sivaramakrishna

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Novel Ni(II) Complexes as Minor Groove Binders: Crystal Structures, Biomolecular Interactions, Molecular Docking, and Biological Activities

Özbağcı

2024

Applied Organom Chemis

View full text Add to dashboard Cite

A novel ternary Ni(II) complexes, [Ni(5Clsal‐phe)(phen)(H2O)] (1) and [Ni(5Clsal‐phe)(bpy)(H2O)]CH3OH (2), (Schiff base derived from the condensation of L‐phenylalanine and 5‐chlorosalicylaldehyde, phen: 1,10‐phenanthroline, bpy: 2,2′‐bipyridine) has been synthesized. The structure of the complexes was clarified by CHN analysis, FTIR, electronic absorption spectroscopy, ESI‐MS, and X‐ray single crystal diffraction methods. In biological activity studies, the interactions of the complexes with calf thymus DNA (CT‐DNA) were examined using fluorescence spectroscopy. The results show that the complexes could bind to CT‐DNA via a minor groove mode. The interactions of the complexes with bovine serum albumin (BSA) were investigated using electronic absorption and fluorescence spectroscopy techniques, and the BSA quenching mechanism was found. The radical scavenging activity of the complexes was investigated in comparison with hederacolchiside, taxifoline, hederasaponin, arachidonoyl dopamine, and silychristin used as standard. Molecular docking simulations were employed to investigate the interactions between the complexes and biomolecules such as DNA and BSA. The results revealed that the complexes insert into DNA via the minor groove and bind to BSA at subdomains I and IIA. These interactions are facilitated by conventional hydrogen bonds, van der Waals forces, alkyl, and π‐alkyl interactions.

show abstract

Novel Ni(II) Complexes as Minor Groove Binders: Crystal Structures, Biomolecular Interactions, Molecular Docking, and Biological Activities

Özbağcı

2024

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Catalytic ethylene oligomerization reactions of terpyridine (NNN)-based nickel(II) complexes – Studies on catalytical intermediates

Panicker,

Vijai Anand,

Boominathan

et al. 2024

Inorganica Chimica Acta

View full text Add to dashboard Cite

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) – A comparative analysis

Pandya,

Sivaramakrishna

2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Studies on synthesis and influence of sterically driven Ni(II)-terpyridine (NNN) complexes on BSA/DNA binding and anticancer activity

Cited by 3 publications

References 49 publications

Novel Ni(II) Complexes as Minor Groove Binders: Crystal Structures, Biomolecular Interactions, Molecular Docking, and Biological Activities

Novel Ni(II) Complexes as Minor Groove Binders: Crystal Structures, Biomolecular Interactions, Molecular Docking, and Biological Activities

Catalytic ethylene oligomerization reactions of terpyridine (NNN)-based nickel(II) complexes – Studies on catalytical intermediates

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) – A comparative analysis

Contact Info

Product

Resources

About

Studies on synthesis and influence of sterically driven Ni(II)-terpyridine (NNN) complexes on BSA/DNA binding and anticancer activity

Cited by 3 publications

References 49 publications

Novel Ni(II) Complexes as Minor Groove Binders: Crystal Structures, Biomolecular Interactions, Molecular Docking, and Biological Activities

Novel Ni(II) Complexes as Minor Groove Binders: Crystal Structures, Biomolecular Interactions, Molecular Docking, and Biological Activities

Catalytic ethylene oligomerization reactions of terpyridine (NNN)-based nickel(II) complexes – Studies on catalytical intermediates

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) – A comparative analysis

Contact Info

Product

Resources

About

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M = Fe(III), Ni(II), Cu(II) and Ru(III)) – A comparative analysis