Studies on Steroidal Enol Ethers: An Attempt to Dissociate Progestational From Contraceptive Activity in Oral Gestagens

Falconi, Giovanni; Gardi, R.; Bruni, Giancarlo; Ercoli, A

doi:10.1210/endo-69-3-638

Cited by 17 publications

(6 citation statements)

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“…It has been well known that the virilization of female offsprings is caused after the maternal administration of some synthetic steroids (Moncriff et al, 1958;Wilkins, 1960;Revesz et al, 1960;Falconi et al, 1961;Suchowsky et al, 1961 and1967;Lerner et al, 1962;Neumann and Junkmann, 1963). Although early workers estimated the activities rather qualitatively by indirect technique (Neumann and Junkmann, 1963;Neumann and Kramer, 1964;Falconi and Rossi, 1965), a new method for the estimation of virilizing activity by measuring the morphological changes in the pelvic region of the female rat fetus directly under microscope was proposed and the virilizing activities of methyltestosterone and norethandrolone were estimated quantitatively in the previous report (Kawashima et al, 1975 The day of as the first day of gestation.…”

Section: Synopsismentioning

confidence: 99%

Virilizing activities of various steroids in female rat fetuses.

et al. 1977

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Section: Synopsismentioning

confidence: 99%

Virilizing activities of various steroids in female rat fetuses.

et al. 1977

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“…Observations that the administration of progestogens to rodents during early pregnancy induces virilization of the foetal genital tract (Mey & Scheid, 1959;Revesz, Chappel & Gaudry, 1960;Falconi, Gardi, Bruni & Ercoli, 1961;Schöler & de Wächter, 1961;Lerner, de Phillipo, Yiacas, Brennan & Borman, 1962;Neumann, Kramer & Junkmann, 1964;Junkmann, 1964;Suchowsky, Turolla & Arcari, 1967) comparable to that produced by androgens, have prompted the present study of the histological changes induced in the embryonic development of the mammary gland by the administration of certain progestogens.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Some Progestogens on the Mammary Gland of the Foetal Mouse During the Period of Initial Differentiation

Cupceancu¹,

Neumann²,

Ulloa³

1969

Journal of Endocrinology

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Progestogens administered to pregnant mice during the initial period of differentiation of the mammary gland rudiment produced various morphological changes in the mammary rudiments of both male and female foetuses.Norethisterone (17\g=a\-ethynyl-\g=D\4-oestrene-17\g=b\-ol-3-one) caused virilization of the rudiments in female foetuses. Medroxyprogesterone acetate (6\g=a\-methyl-\g=D\4-pregnene-17\g=a\-ol-3,20-dione-17\g=a\-acetate)produced virilization of the rudiments in female and feminization in male foetuses. Gestonorone caproate (19-nor-\g=D\4-pregnene-17\g=a\-ol-3,20-dione-17\g=a\-caproate) and allyloestrenol (17\g=a\-allyl-\g=D\4-oestren-17\g=b\-ol) tended to cause feminization of some of the mammary rudiments.

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“…Though many studies on enol ether analogues of progesterone (2)(3)(4)(5)(6)(7) and certain androgens (2,7,(8)(9)(10)(11) have been reported, little is known about similar derivatives of 19-nortestosterone. Experiments with the 3-cyclopentyl enol ether of 17aethynyl-19-nortestosterone-l7p-acetate [ quingestanol acetate (QA)] showed that enol etherification generally enhances most biological activities as compared with its parent ketone (2,4,5,7,12).…”

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confidence: 99%