Studies on Sociodemography, Clinical, Laboratory, and Treatment of Fascioliasis Patients in Assiut Hospitals, Assiut Governorate, Egypt

HUSSIEUN, SAMAH; Mohamed, Yasser Mahmoud A.; Bakir, Hanaa Y.; Othman, Ragaa A.; Abdel-Rahman, Salma M.; Khalifa, Mervat M.

doi:10.21608/jesp.2022.235834

Cited by 1 publication

(3 citation statements)

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“…This could be owing to most patients in our study were in the acute phase and some patients did not do stool analysis for eggs (children and a few adults). This is in agreement with studies conducted by Ali et al and Hussieun et al 28 , 38 . Serodiagnosis of fascioliasis in human and animal species has been successfully carried out employing several antigenic fractions of Fasciola , purified antigens and recombinant antigens.…”

Section: Discussionsupporting

confidence: 94%

“…In this study, there is a significant correlation between eosinophilia and Fasciola antibody titer before and after treatment. This is in agreement with the results of El Mekky et al and Hussieun et al 24 , 28 . All patients were treated with oral triclabendazole, and most cases responded well to a single dose of 10 mg/kg of triclabendazole.…”

Section: Discussionsupporting

confidence: 93%

“…Assiut Governorate, which is located in Upper Egypt, expressed the vast majority of our recruited cases and most of them were from rural communities, especially Manfalout District. This explains the occurrence of an outbreak of fascioliasis in this district during the study period which was reflected on the number of cases from Assiut, however this is not the true situation in Assiut or even in Egypt which is in concordance with the findings of Ramadan et al and Hussieun et al 27 , 28 . Most of the included patients were young which could be due to the exposure pattern of those who work on farms to be more liable to disease.…”

Section: Discussionsupporting

confidence: 87%

See 2 more Smart Citations

Clinical characteristics of human fascioliasis in Egypt

Ibrahim,

Abdel Khalek,

Makhlouf

et al. 2023

Sci Rep

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There is a lack of epidemiological data on fascioliasis in Egypt regarding disease characteristics and treatment outcomes across different governorates. We aimed to identify the demographic, epidemiologic, clinical, laboratory, and radiological characteristics and treatment outcomes of patients diagnosed with fascioliasis in Egypt. Data on human fascioliasis were collected retrospectively from patients’ medical records in the period between January 2018 and January 2020. The study included 261 patients. More than 40% of enrolled patients were in the age group of 21–40 years old. Geographically, 247 (94.6%) were from Assiut Governorate with 69.3% were from rural areas. The most frequent symptoms were right upper quadrant pain (96.9%), and fever (80.1%). Eosinophilia was found in 250 cases (95.8%). Hepatic focal lesions were detected in 131 (50.2%); out of them 64/131 (48.9%) had a single lesion. All patients received a single dose of 10 mg/kg of triclabendazole, 79.7% responded well to a single dose, while in 20.3% a second ± a third dose of treatment was requested. After therapy, there was a reduction in leucocytes, Fasciola antibodies titer, eosinophilic count, bilirubin, and liver enzymes with an increase in hemoglobin level. According to our findings, a high index of suspicion should be raised in cases with fever, right upper abdominal pain, and peripheral eosinophilia, and further imaging workup is mandated to detect hepatic focal lesions. Prompt treatment by triclabendazole can serve as a standard-of-care regimen even for suspected cases.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%