Studies on Similarity Diagnosis in Twins With the Aid of Mailed Questionnaires

Cederlöf, R.; Friberg, L; Jönsson, Erik; Kaij, L.

doi:10.1159/000151168

Cited by 215 publications

(166 citation statements)

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“…Without undue expense we have located more than 80% of the still intact twin pairs and obtained biographical (including zygosity) data from 80% of those located. It should be noted that the large registries in Finland and in Sweden [8] obtained questionnaire returns from 89% and 83%, respectively, of the individual twins solicited. Whether this achievement reflects cultural differences or a more skillful solicitation than ours cannot be decided on the available evidence.…”

Section: Discussionmentioning

confidence: 99%

The Minnesota Twin Family Registry: Some Initial Findings

Lykken

Bouchard

McGue

et al. 1990

Acta genet. med. gemellol.: twin res.

299

192

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Abstract. A birth-record based Registry is nearing completion of some 8,000 pairs of twins born in Minnesota from 1936 to 1955, plus some 1,200 pairs of male twins born 1971-81. The middle-aged twins were recruited with graded incentives so that ease of recruitment could be measured; it was found that pairs concordant for ease of recruitment were no more similar than discordant pairs in education, socioeconomic status (SES), or a variety of personality and interest factors, ie, that selection bias may not be a problem in research with adult twins when contacts are only by mail. A 50% decrease in neonatal mortality from 1936-55 to 1971-81 was associated with an increase from 3.5 to 4.0 per thousand in the frequency of viable MZ twin births. The broad heritability of SES, educational attainment, fecundity, and risk for divorce ranges from 0.30 to 0.50, although all 4 variables are plainly multifactorial and the latter 2 both involve variance contributed by a second person. Investigators interested in making use of this research resource are invited to submit proposals.

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Section: Discussionmentioning

confidence: 99%

The Minnesota Twin Family Registry: Some Initial Findings

Lykken

Bouchard

McGue

et al. 1990

Acta genet. med. gemellol.: twin res.

299

192

View full text Add to dashboard Cite

show abstract

“…The information about zygosity collected by the questionnaires in 1998 and 2002 was based on validated questions of similarity in childhood and difficulties teachers might have had in distinguishing between the twins 8,9 . In 2003, twins belonging to complete pairs of undetermined zygosity were offered a DNA test.…”

Section: Methodsmentioning

confidence: 99%

Physical activity, diet and gene–environment interactions in relation to body mass index and waist circumference: The Swedish Young Male Twins Study

Karnehed

Tynelius²,

Heitmann

et al. 2006

Public Health Nutr.

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Objective: The aim of the present study was to examine the relationships between genetic susceptibility to obesity, physical activity (PA), dietary fibre, sugar and fat intakes and 4-year changes in body mass index (BMI) and attained waist circumference (WC) in a cohort of 287 monozygotic and 189 dizygotic young adult male twin pairs. Increased knowledge about interactions between genes and environment may provide insight into why some individuals are more prone to obesity than others. Design: Information about PA, BMI, dietary habits, WC and potential confounders was collected by questionnaire in 1998 and 2002. The cohort data were analysed by mixed linear models. Results: Twins with low PA attained larger WC than twins with high PA (difference 2.5 cm; 95% confidence interval (CI) 1.3, 3.6). The twins with the lowest fibre intake were found to have attained the highest WC and to have increased most in BMI (difference between highest and lowest fibre intakes: 1.6 cm, 95% CI 0.4, 2.9 and 0.45 kg m 22 , 95% CI 0.15, 0.76, respectively). Furthermore, our results suggested the presence of interactions so that twins with genetic susceptibility to obesity were more prone to have larger WC if sedentary than twins without genetic susceptibility. Conclusion: PA and a diet rich in fibre may be protective against weight gain among younger adult men. An interaction between PA, genes and attained WC is a novel finding which needs confirmation by other studies.

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“…After consent from each twin, the medical notes of all twins were evaluated, to verify or refute the diagnosis of IBD and to characterize the disease according to the Montreal classification (Satsangi et al, 2006). Zygosity was assessed by a questionnaire-based method, applied by the Swedish twin registry (Cederlö f et al, 1961). It relies on questions on childhood resemblance and has been shown to be very accurate (Lichtenstein et al, 2002).…”

Section: Patient Cohortmentioning

confidence: 99%

Molecular analysis of the gut microbiota of identical twins with Crohn's disease

et al. 2008

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Increasing evidence suggests that a combination of host genetics and the composition of the gut microbiota are important for development of Crohn's disease (CD). Our aim was to study identical twins with CD to determine microbial factors independent of host genetics. Fecal samples were studied from 10 monozygotic twin pairs with CD (discordant n ¼ 6 and concordant n ¼ 4) and 8 healthy twin pairs. DNA was extracted, 16S rRNA genes were PCR amplified and T-RFLP fingerprints generated using general bacterial and Bacteroides group-specific primers. The microbial communities were also profiled based on their percentage G þ C contents. Bacteroides 16S rRNA genes were cloned and sequenced from a subset of the samples. The bacterial diversity in each sample and similarity indices between samples were estimated based on the T-RFLP data using a combination of statistical approaches. Healthy individuals had a significantly higher bacterial diversity compared to individuals with CD. The fecal microbial communities were more similar between healthy twins than between twins with CD, especially when these were discordant for the disease. The microbial community profiles of individuals with ileal CD were significantly different from healthy individuals and those with colonic CD. Also, CD individuals had a lower relative abundance of B. uniformis and higher relative abundances of B. ovatus and B. vulgatus. Our results suggest that genetics and/or environmental exposure during childhood, in part, determine the gut microbial composition. However, CD is associated with dramatic changes in the gut microbiota and this was particularly evident for individuals with ileal CD.

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Studies on Similarity Diagnosis in Twins With the Aid of Mailed Questionnaires

Cited by 215 publications

References 0 publications

The Minnesota Twin Family Registry: Some Initial Findings

The Minnesota Twin Family Registry: Some Initial Findings

Physical activity, diet and gene–environment interactions in relation to body mass index and waist circumference: The Swedish Young Male Twins Study

Molecular analysis of the gut microbiota of identical twins with Crohn's disease

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