Studies on Sida Acuta Hydrogel I: Processing and Physicochemical Properties of the Derived Hydrogel Obtained From South East Nigeria

Abstract

Objective: Sida acuta is a plant that is widely distributed in the subtropical regions where it is found in bushes, in farms and around habitations. This study was carried out to isolate hydrogel from this freely available natural source. Methods:The sieved dried powder from the leaves of Sida acuta was macerated in distilled water. The mucilage formed was filtered and precipitated with equal volumes of isopropyl alcohol. This was repeated using ethanol and acetone respectively. The precipitated hydrogel was purified by washing twice with isopropyl alcohol, once with acetone and dried in the oven at 40 °C for 8h. Results:The mean percentage yield of the hydrogel as obtained was 10.15±1.22, 9.24±0.74 and 7.90±0.03 %w/w for isopropyl alcohol, ethanol and acetone precipitated hydrogels respectively. The swelling index of the hydrogel in water was 10.00±0.02. The solubility of the hydrogel in water at 28 °C and 80 °C were 7.00±0.41 and 8.63±0.63 respectively. The solubility of the hydrogel in 0.1 N NaOH and 0.1 N HCl solutions were 11.86±1.75 and 5.67±0.58 mg/ml respectively. The loss on drying was 14 5±1.87% while total ash was 53.33±5.77 mg per 1 g hydrogel. The viscosity of a 1%w/v solution of the hydrogel using rotor 1 of a Brookfield viscometer at 30 rpm was 71.4±0.00 mPas. The pH of a 1%w/v solution was 6.60±009. The Carr's index and Hausner ratio were 38.77±1.69% and 1.63±0.05 respectively. Conclusion:The hydrogel obtained from powdered dried leaves of Sida acuta may have potential in various drug delivery systems.

Gas Chromatography and Mass Spectrometry of the Ethanolic Extract of Nest Material of Mud Dauber Wasp, Sceliphron Caementarium

“…[30]. These steroids have been reported to have capacity to lessen anxiety, seizures, premenstrual disorders, mood disorders, depression, and stress, for treating memory and neural system damage [31,32]. Although the Eicosanoic acid shows only 2% of the nest extract, it possesses anti-inflammatory and hepatoprotective properties [33].…”

Formulation and Evaluation of Sustained Release Tablet of Metformin by Ionic Gelation Technique using Sida acuta Gum as Release Retardant

“…The method of 14 was used. A 150 g quantity of powdered dried Sida acuta leaves was macerated for 9 hours using 1.5 litres of distilled water.…”

“…13 Sida acuta gum is isolated from the powdered dried leaves of Sida acuta. 14 Sida acuta gum has been used as binder, 15 as suspending agent 16 , as polymer matrix former 17 and as mucoadhesive polymer. 18 Metformin is a biguanide antihyperglycemic agent which is used with proper diet and exercise program to improve glucose tolerance in Type 2 (non-insulin dependent) diabetes mellitus patients and lower both basal and postprandial plasma glucose.…”

Hydrogel Formulation From Calotropis Gigantea Plant Extract Against Foot Ulcer Causing Bacteria in Diabetes

“…The powder was then subjected to solvent extraction using ethanol, butanol, and acetone. A 10% W/V of the powder is mixed in each of the selected solvents, and left as such in a shaker incubator for 24 h. After incubation the content is filtered using a Whatman filter paper and the filtrate mixture containing the specified active factor was dried out to concentrate the active factor [3]. The hydrogel obtained from powdered dried leaves may have potential in various drug delivery systems [4].…”