Studies on shrinkage, depth of cure, and cytotoxic behavior of novel organically modified ceramic based dental restorative resins

Lizymol, P. P.

doi:10.1002/app.31762

Cited by 12 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The percentage linear polymerization shrinkage was evaluated as previously described [18]. In brief, shell nacre cement paste was packed in a 6 mm diameter and 3 mm height stainless steel mould and allowed to cure.…”

Section: Evaluation Of Linear Polymerization Shrinkage (Lps)mentioning

confidence: 99%

“…It is easily synthesized by a modified sol-gel method using methacrylate-substituted alkoxysilanes through the process of hydrolysis and condensation to form the inorganic siloxane network, whereas the methacrylate moieties remain intact [17]. It has been widely investigated in the field of dental cements due to its non-cytotoxic nature, low polymerization shrinkage, and superior mechanical properties [18][19][20][21], particularly the photocured cured composites of ladder-structured siloxane methacrylate resin [22]. However, there is no report of usage of this resin for orthopaedic applications to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Bone Void Filling Cement Compositions Based on Shell Nacre and Siloxane Methacrylate Resin: Development and Characterization

Wilson,

Philipose Pampadykandathil

2023

Bioengineering

View full text Add to dashboard Cite

Shell nacre from Pinctada species has been extensively researched for managing bone defects. However, there is a gap in the research regarding using shell nacre powder as a cement with improved biological and physicochemical properties. To address this, bone void filling cement was formulated by incorporating shell nacre powder and an organically modified ceramic resin (ormocer). The shell nacre powder was specifically processed from the shells of Pinctada fucata and analysed using thermogravimetric analysis (TGA), X-ray diffraction spectroscopy, Fourier transform infrared (FTIR), and Raman spectroscopy, confirming the presence of organic constituents and inorganic aragonite. Trace element analysis confirmed the eligibility of shell nacre powder for biomedical applications. Next, the ormocer SNLSM2 was synthesized through a modified sol–gel method. FTIR, Raman, TGA, and transmission electron microscopy studies revealed the presence of a ladder-structured siloxane backbone and methacrylate side chain. To develop chemical curable composite shell nacre cement (SNC), different amounts of shell nacre (24%, 48%, and 72%) were added to the SNLSM2 resin, and the impact on the physicochemical properties of the cement was studied. Among the compositions, SNC 72 exhibited significantly lower linear polymerization shrinkage (0.4%) and higher compressive (>100 MPa) and flexural strength (>35 MPa). SNC 72 was radiopaque, and the exotherm generated during the cement curing was minimal. Cytotoxicity studies with L929 cells revealed the non-cytotoxic nature of the cement. Overall, the findings of this study prove that the shell nacre cement is a promising candidate for managing bone voids.

show abstract

Section: Evaluation Of Linear Polymerization Shrinkage (Lps)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Bone Void Filling Cement Compositions Based on Shell Nacre and Siloxane Methacrylate Resin: Development and Characterization

Wilson,

Philipose Pampadykandathil

2023

Bioengineering

View full text Add to dashboard Cite

show abstract

“…The major composition of the cement is shell nacre, the inner lustrous layer of pearl oyster shell, which has demonstrated osteogenic, anti-osteoporotic and angiogenic potentials [39][40][41]. Another prime constituent is ladder-structured siloxane methacrylate (SNLSM2), an inorganicorganic hybrid resin known for its low shrinkage and good mechanical properties [42,43]. In combination with SNLSM2, SNC exhibited higher compressive strength, low polymerization shrinkage, minimal exothermic behaviour and no cytotoxicity against the L929 cell line.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Osteogenesis Study of Shell Nacre Cement with Older and Young Donor Bone Marrow Mesenchymal Stem/Stromal Cells

Wilson,

Owston,

Iqbal

et al. 2024

Bioengineering

View full text Add to dashboard Cite

Bone void-filling cements are one of the preferred materials for managing irregular bone voids, particularly in the geriatric population who undergo many orthopedic surgeries. However, bone marrow mesenchymal stem/stromal cells (BM-MSCs) of older-age donors often exhibit reduced osteogenic capacity. Hence, it is crucial to evaluate candidate bone substitute materials with BM-MSCs from the geriatric population to determine the true osteogenic potential, thus simulating the clinical situation. With this concept, we investigated the osteogenic potential of shell nacre cement (SNC), a bone void-filling cement based on shell nacre powder and ladder-structured siloxane methacrylate, using older donor BM-MSCs (age > 55 years) and young donor BM-MSCs (age < 30 years). Direct and indirect cytotoxicity studies conducted with human BM-MSCs confirmed the non-cytotoxic nature of SNC. The standard colony-forming unit-fibroblast (CFU-F) assay and population doubling (PD) time assays revealed a significant reduction in the proliferation potential (p < 0.0001, p < 0.05) in older donor BM-MSCs compared to young donor BM-MSCs. Correspondingly, older donor BM-MSCs contained higher proportions of senescent, β-galactosidase (SA-β gal)-positive cells (nearly 2-fold, p < 0.001). In contrast, the proliferation capacity of older donor BM-MSCs, measured as the area density of CellTrackerTM green positive cells, was similar to that of young donor BM-MSCs following a 7-day culture on SNC. Furthermore, after 14 days of osteoinduction on SNC, scanning electron microscopy with energy-dispersive spectroscopy (SEM-EDS) showed that the amount of calcium and phosphorus deposited by young and older donor BM-MSCs on SNC was comparable. A similar trend was observed in the expression of the osteogenesis-related genes BMP2, RUNX2, ALP, COL1A1, OMD and SPARC. Overall, the results of this study indicated that SNC would be a promising candidate for managing bone voids in all age groups.

show abstract

“…[1]. Most of the commercially available dimethacrylate resin shows polymerization shrinkage [2]. Although these conventional restorative materials have proven to be effective at preserving teeth, they have a limited life-span and ultimately require replacement.…”

Section: Introductionmentioning

confidence: 99%

Physical and Mechanical Properties of Visible Light Cure Composites Based on Novel Organically Modified Ceramic Resins

Lizymol

2013

AMR

View full text Add to dashboard Cite

Replacement of damaged tooth is necessary for proper functioning and better aesthetics. Polymeric composites based on organic resins are the most popular materials used for restoration of damaged tooth though they have many problems like polymerization shrinkage. The post gel polymerization shrinkage causes significant stresses in the surrounding tooth structure and composite tooth bonding leading to premature restoration failure. Other problems such as uncured organic monomers leaching from the dental composites into the surrounding gum tissue have been reported to cause cytotoxic effects, pulpal necrosis, requiring tooth extraction. The present paper describes the studies on visible light cure composites based on organically modified ceramic resins. Effect of different inorganic materials incorporated during resin synthesis on mechanical properties of photo cured composite was evaluated in terms of diametral tensile strength (DTS), compressive strength (CS) and surface hardness (VHN). The better properties of photocured composites based on the novel organically modified ceramic resin which are hybrid inorganic organic resins may be due to the effective bonding between the organic and inorganic parts within the resin.

show abstract

Studies on shrinkage, depth of cure, and cytotoxic behavior of novel organically modified ceramic based dental restorative resins

Cited by 12 publications

References 13 publications

Novel Bone Void Filling Cement Compositions Based on Shell Nacre and Siloxane Methacrylate Resin: Development and Characterization

Novel Bone Void Filling Cement Compositions Based on Shell Nacre and Siloxane Methacrylate Resin: Development and Characterization

In Vitro Osteogenesis Study of Shell Nacre Cement with Older and Young Donor Bone Marrow Mesenchymal Stem/Stromal Cells

Physical and Mechanical Properties of Visible Light Cure Composites Based on Novel Organically Modified Ceramic Resins

Contact Info

Product

Resources

About