Studies on serum selenium and tocopherol in white muscle disease of foal.

Higuchi, Tohru; Ichijo, Shigeru; Osame, Satoshi; Ohishi, Hideo

doi:10.1292/jvms1939.51.52

Cited by 29 publications

(23 citation statements)

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“…Our results are consistent with those of Abutarbush and Radostits [1], Aiello and Mays [23], and Kiroloss et al [31]. It is well known that vitamin E and selenium act synergistically to minimize propagation of oxidative damage to cell membranes in WMD [20][21][22][23]. Their decrease might increase free-radical production, contributing to pathological changes in the diaphragm, heart, and skeletal muscle tissues.…”

Section: Resultssupporting

confidence: 92%

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Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs with White Muscle Disease

Değer

Mert

et al. 2007

Biol Trace Elem Res

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The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blood samples were collected from both groups before- and 1 month after treatment for Se analysis by fluorimetry, whereas vitamin E and sialic acid were measured by HPLC and spectrophotometry, respectively. Compared to controls, in the diseased animals, there was a significant increase of serum total sialic acid (TSA) and LBSA, together with significant decreases of serum Se and vitamin E concentrations (p < 0.001). One month after treatment, a reversal of trend was observed with decreases of TSA and LBSA and increases of Se and vitamin E concentrations. The TSA and LBSA levels, however, remained significantly higher than those of the controls, p < 0.05 and 0.001, respectively. The Se and vitamin E concentrations of the treated animals were the same as those of controls. This is the first study on total and LBSA concentrations in lambs with WMD, showing that these markers can be used in the prognosis of the disease.

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Section: Resultssupporting

confidence: 92%

“…In the present case, the levels of both vitamin E and selenium were significantly lower in diseased animals than in the healthy lambs [20][21][22][23]. It was particularly emphasized that Se deficiency is one of the most important reasons for WMD [24,25].…”

Section: Resultsmentioning

confidence: 62%

Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs with White Muscle Disease

Değer

Mert

et al. 2007

Biol Trace Elem Res

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“…Deficiencies of either alpha-tocopherol or selenium also occur naturally. For example, White muscle disease (WMD) is seen in farm animals and arises as a consequence of a combination of inadequate soil selenium and enhanced oxidation of alpha-tocopherol in foodstuffs or diets poor in alpha-tocopherol (12)(13)(14)(15)(16)(17)(18)(19)(20). In animals with WMD, alpha-tocopherol and selenium contents of affected muscle are reduced with consequential reductions in glutathione peroxidase in plasma (15).…”

Section: Effects Of Selenium and Alpha-tocopherol Deficiencies On Skementioning

confidence: 99%

Oxidants antioxidants and alcohol implications for skeletal and cardiac muscle

Preedy¹

1999

Front Biosci

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“…Miodegeneração nutricional, também conhecida como distrofia muscular nutricional, miodegeneração distrófica, miodistrofia nutricional ou doença do músculo branco, é uma afecção hiperaguda, aguda ou subaguda da musculatura estriada cardíaca e/ou esquelética causada pela deficiência de selênio (Se) e ocasionalmente vitamina E (tocoferol) (Higuchi et al 1989).…”

Section: Introductionunclassified

Aspectos morfológicos de biópsias musculares em equinos com miopatia sob forma de surto

et al. 2011

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Pesq. Vet. Bras. 31(7):579-585, julho 2011 RESUMO.-As miopatias em equinos são classificadas de acordo com aspectos clínicos, morfológicos e moleculares, em três grandes grupos: não associadas ao exercício, associadas ao exercício e devido alteração da condução elétrica do sarcolema. Apesar dos avanços no diagnóstico, a literatura ainda relata surtos de miopatia em equinos sem etiologia esclarecida em diversos países. O objetivo desse estudo foi descrever as alterações histológicas e histoquímicas de biópsias musculares de equinos acometidos por miopatia. Sete equinos da raça Quarto de Milha, com 18-24 meses de idade, apresentaram sinais clínicos de miopatia. Dentre esses animais, cinco apresentaram sinais subagudos leves a moderados e dois apresentaram sinais hiperagudos severos e decúbito lateral. Foram realizadas biópsias musculares utilizando a técnica percutâ-nea, por agulha tipo Bergström, no músculo glúteo médio em todos os animais acometidos. As amostras foram processadas por meio de técnicas histológicas (HE, Tricrômio de Gomori modificado) e histoquímicas (PAS, NADH, ATPase). Nos quadros clínicos mais leves, a principal alteração encontrada foi a presença de fibras vermelhas rajadas do tipo I e Equine myopathies are classified according clinic, morphologic and molecular features in three groups: Non-exertional, exertional, and abnormal muscle membrane conduction. In spite the advances in diagnostic, the literature has reported outbreaks of equine myopathy without clear etiology in several countries. The aim of this study was to describe the histological and histochemical findings of muscle biopsies in an outbreak of equine myopathy. Seven 18 to 24-month-old Quarter horses showed clinical signs of myopathy. Five horses presented mild clinical signs and two horses had severe clinical signs with recumbency. Muscle biopsies were obtained from gluteal medium muscle by percutaneous technique with Bergstrom needle in all affected horses. Muscle samples were processed by histological (HE, modified gomori-trichrome) and histochemical (PAS, NADH, ATPase) technics. In animals with mild clinical signs, ragged red fibers type I and IIA, related to the oxidative metabolism dysfunction of mitochondria, was the main abnormality found. Muscle fiber atrophy and presence of subsarcolemmal aggregates in type I and IIA muscle fibers were also observed. More severe affected horses presented inflammatory infiltrate, proliferation of collagen, phagocytosis, necrosis and calcification. Based on the morphological findings, vitamin E therapy response associated with the low mortality when compared with atypical myopathy reports, We concluded that this outbreak was triggering for mitochondrial lesions, characterized by ragged red muscle fibers, probably due a breakdown homeostasis in vitamin E and Se, being compatible with nutritional myopathy diagnosis.INDEX TERMS: White muscle disease, nutritional myopathy, atypical myopathy, ragged red fibers.

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Studies on serum selenium and tocopherol in white muscle disease of foal.

Cited by 29 publications

References 0 publications

Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs with White Muscle Disease

Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs with White Muscle Disease

Oxidants antioxidants and alcohol implications for skeletal and cardiac muscle

Aspectos morfológicos de biópsias musculares em equinos com miopatia sob forma de surto

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