Studies on Serum Lipids, Proteins, and Lipoproteins in Psoriasis11From the Department of Dermatology and Syphilology, Medical School, and the Institute of Industrial Health, University of Michigan, Ann Arbor, Michigan.

Lea, Walker A.; Cornish, Herbert H.; Block, Walter D.

doi:10.1038/jid.1958.34

Cited by 21 publications

(2 citation statements)

References 17 publications

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“…So far, the investigation of psoriatic proteins with several proteomics technique analysis has revealed the structure and location of many proteins (Table I). Lea et al, in 1958, working with serum, revealed changes in proteins in patients with psoriasis based on electrophoresis (46). More than 1,200 proteins were identified by Lundberg and his team, utilizing preclinical experiments.…”

Section: Proteomics Research Leads To Novel Biomarkers In Psoriasismentioning

confidence: 99%

Proteomics in Psoriasis: Recent Advances

LEOTSAKOS,

KATAFIGIOTIS,

LEOTSAKOS

et al. 2024

In Vivo

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Psoriasis continues to affect a large percentage of patients worldwide and strongly appears to be a systematic disease. Efforts are being made to understand its etiology, which have led to research extended to genomic analysis with a focus on the role of pro-inflammatory cytokines, which play a major role in the pathogenesis of the disease. Plasma proteomic analysis in various diseases has provided promising results for choosing the right treatment for psoriasis, suggesting that it could play a key role in the prevention, prognosis, and treatment of the disease by individualizing treatment choices based on the proteomic profile of each patient. In this review, we focus on existing data in the bibliography on proteomic analysis in psoriasis and relevant approaches to future targeted therapies.Psoriasis remains a chronic inflammatory condition of the skin and joints. It is estimated to affect millions of people worldwide; however, its aetiology has still not been fully elucidated. Apparently, it is a multifactorial disease influenced by exogenous and endogenous factors, which define the clinical symptoms, signs, and severity of the disease (1).The incidence of this condition in Caucasian children has significantly increased over time, with the chronic plaque type appearing to dominate (73.7%). The extremities (59.9%) and the scalp (46.8%) are the most affected sites. The incidence of the disease increases with age; however, it is not different between both sexes (2). A recent German study showed a rise in incidence in men compared to women, peeking in midlife, and declining from the age of 60, in both sexes (3). It seems that the annual incidence of this disease has increased in the last 40 years for unknown reasons; changes in the diagnostic patterns developed recently could be one factor (4). It is important to note that, psoriasis ranks second in the list of diseases associated with depression (5).Many studies have investigated psoriasis and its role in the systemic comorbidities such as: cardiometabolic diseases (6, 7), gastrointestinal diseases (8, 9) chronic kidney disease (CKD) (10), malignancy (11), infection (12, 13), mental health issues (14, 15), and psoriatic arthritis (PsA) ( 16). Severe psoriasis is associated with an increased risk of death, primarily due to cardiovascular events (17). Overweightness and obesity, more common among psoriatic patients, increase the severity the disease (18). In 1961, Reed et al. first investigated the high prevalence of thrombosis or myocardial infarction (MI) in necropsy material from psoriatic arthritis patients (19). During the last decades, there has been increasing epidemiological evidence supporting the identification of more systemic diseases as extracutaneous medical conditions related to psoriasis. For example, eye manifestations and complications can be seen in psoriasis arthritis patients, symptoms usually not investigated by physicians (20, 21). There is an increasing prevalence of comorbidities associated with psoriasis on a global scale 1000

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Section: Proteomics Research Leads To Novel Biomarkers In Psoriasismentioning

confidence: 99%

Proteomics in Psoriasis: Recent Advances

LEOTSAKOS,

KATAFIGIOTIS,

LEOTSAKOS

et al. 2024

In Vivo

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“…Since more than 60 years, [13] recorded elevated serum lipids level in psoriatic patients. Modern advances in the comprehension of inflammatory cell's role in psoriasis pathogenesis has shifted the clinical point of view on psoriasis from dermal disorder to systemic inflammatory approach, which might raise the propagation of additional comorbid conditions in such population [8].…”

Section: Journal Of University Of Anbar For Pure Science (Juaps)mentioning

confidence: 99%

Evaluation of Lipid profiles in psoriasis patients

Mualla,

Salman,

AlChalabi

2023

JUAPS

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Psoriasis is a skin condition that causes flaky patches of skin which form scales normally appear on elbows, knees, scalp and lower back, also can appear anywhere on body. This study aims to evaluate the correlation between lipid profile variables with the psoriasis development within group subjects. The study included 310 patients, males and females aged (25-65) years. The patients were attending a dermatology consultant at Al-Yarmouk Teaching Hospital in Baghdad. Blood samples were collected by venipuncture from all individuals. Biolis 24i automated analyzer was used to estimate serum levels of Cholesterol, Triglyceride, HDL, LDL, and VLDL. The incidence, prevalence, and manifestation of skin psoriasis are similar between different sexes, there is overexpression of lipid profile related tests, as these variables could impact each other. High levels of Cholesterol, Triglyceride, HDL, LDL, and VLDL in psoriatic patients were recorded when compared with controls. However, it was found that considerable effect of the progression of psoriasis on the elevated lipid profile levels in such individuals. The incidence and prevalence of the disease similar in both sexes. However, all physiological levels of understudy variables were increased in patients with psoriasis, and this may play a major role in the disease development. .

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Changes in Serum Lipoproteins in Psoriasis

Shapiro¹

1960

Arch Dermatol

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Studies on Serum Lipids, Proteins, and Lipoproteins in Psoriasis11From the Department of Dermatology and Syphilology, Medical School, and the Institute of Industrial Health, University of Michigan, Ann Arbor, Michigan.

Cited by 21 publications

References 17 publications

Proteomics in Psoriasis: Recent Advances

Proteomics in Psoriasis: Recent Advances

Evaluation of Lipid profiles in psoriasis patients

Changes in Serum Lipoproteins in Psoriasis

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