Studies on serum immunoreactive prolyl 4-hydroxylase in liver diseases — its elevation both in hepatocellular damage and cholestatic diseases

Nagai, Yusuke; Yoshiba, Makoto

doi:10.1016/0009-8981(88)90032-0

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Moritz M Ziegler1

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1990

2012

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Article6

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Cited by 9 publications

(1 citation statement)

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“…A number of reports have indicated that serum PH levels and serum aminotransferases behave similarly in hepatocellular damage-both clinically and experimentally [5].…”

Section: Moritz M Zieglermentioning

confidence: 99%

Are serum prolyl 4-hydroxylase useful as noninvasive markers of liver fibrosis in patients with biliary atresia?

Kobayashi¹,

Tamura²,

Yamataka³

et al. 2005

Journal of Pediatric Surgery

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“…A number of reports have indicated that serum PH levels and serum aminotransferases behave similarly in hepatocellular damage-both clinically and experimentally [5].…”

Section: Moritz M Zieglermentioning

confidence: 99%

Are serum prolyl 4-hydroxylase useful as noninvasive markers of liver fibrosis in patients with biliary atresia?

Kobayashi¹,

Tamura²,

Yamataka³

et al. 2005

Journal of Pediatric Surgery

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Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats

Kobuchi

Ito

Okada

et al. 2012

Eur J Drug Metab Pharmacokinet

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To investigate the hepatic dihydropyrimidine dehydrogenase (DPD) activity in colorectal cancer (CRC), which is critically important to create a patient-specific dosing regimen, we performed 5-FU pharmacokinetic studies in 1,2-dimethylhydrazine-induced CRC model rats (CRC rats). After rats received 5-FU intravenous (IV) bolus injections, the area under the plasma concentration-time curve (AUC) and elimination half-life (t 1/2) in CRC rats (10.02 ± 0.37 μg h mL(-1), 0.30 ± 0.02 h, respectively) were significantly lower than that in control rats (13.46 ± 1.20 μg h mL(-1), 0.52 ± 0.05 h, respectively), whereas total plasma clearance (CLtot) in CRC rats (2.01 ± 0.07 L h(-1) kg(-1)) was significantly increased compared with that in control rats (1.54 ± 0.14 L h(-1) kg(-1)). Conversely, the avoidance ratio of the hepatic first-pass effect was approximately 20 % lower than that in control rats. Of interest is that hepatic DPD activity levels and the dihydrouracil-uracil ratio (UH2/Ura ratio) in plasma, which may act as a potential biomarker to evaluate hepatic DPD activity levels, were significantly increased in CRC rats. These results suggest that the decrease of hepatic availability in CRC rats is brought about by the increase in intrinsic clearance induced by the increase in DPD activity, resulting in a decrease in AUC and t 1/2 and an increase in CLtot after 5-FU IV bolus injection. Along with a proper dosing regimen for patients with CRC, a hepatic DPD activity monitoring system, such as the determination of UH2/Ura ratio in plasma, is desirable.

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Serum immunoreactive prolyl 4-hydroxylase as a specific marker of hepatocellular necrosis

Nagai

Toda

1990

Clinica Chimica Acta

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Studies on serum immunoreactive prolyl 4-hydroxylase in liver diseases — its elevation both in hepatocellular damage and cholestatic diseases

Cited by 9 publications

References 21 publications

Are serum prolyl 4-hydroxylase useful as noninvasive markers of liver fibrosis in patients with biliary atresia?

Are serum prolyl 4-hydroxylase useful as noninvasive markers of liver fibrosis in patients with biliary atresia?

Pharmacokinetics of 5-fluorouracil and increased hepatic dihydropyrimidine dehydrogenase activity levels in 1,2-dimethylhydrazine-induced colorectal cancer model rats

Serum immunoreactive prolyl 4-hydroxylase as a specific marker of hepatocellular necrosis

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