Studies on Renal Adaptation to Altered Dietary Amino Acid Intake: Tissue Taurine Responses in Nursing and Adult Rats

Chesney, Russell W.; Lippincott, Shirley E.; Gusowski, Naomi; Padilla, Marcia L.; Zelikovic, Israel

doi:10.1093/jn/116.10.1965

Cited by 39 publications

(20 citation statements)

References 23 publications

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“…Many biological effects of taurine rely upon its intracellular concentration, which primarily controls CDO and CSD [25,27] and TauT. The plasma taurine concentration is 40-100 mM, but in myocardium taurine concentration is demonstrated to be as high as 30 mM, as heart has limited ability to synthesize taurine to overcome [28]. This phenomenon may mainly rely upon uptaking taurine by TauT, which is a high-affinity and low-capacity sodium-and chloride-dependent transporter [29,30].…”

Section: Discussionmentioning

confidence: 99%

Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes

Yang

Zhang

Liu

et al. 2013

ABBS

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Taurine, a conditionally essential amino acid, plays a critical role in cardiovascular function. Here we examined the effect of taurine on mitochondria and endoplasmic reticulum in rat cardiomyocytes during glucose deprivation (GD). Data showed that cell viability, intracellular taurine contents, and taurine transporter expression were decreased during GD. In contrast, an increase in reactive oxygen species and intracellular Ca 21 contents was observed. GD also caused disrupted mitochondrial membrane potential, apoptotic cell death, and dissociation of unfolded protein response (UPR)-relative proteins in cardiomyocytes. Signal transduction analysis showed that Bcl-2 family protein balance was disturbed, caspase-12 was activated and UPR-relative protein levels were up-regulated. Moreover, pre-treatment with 80 mM exogenous taurine attenuated GD effect in cardiomyocytes. Our results suggest that taurine have beneficial effects on inhibiting mitochondria-dependent cell apoptosis and UPR-associated cell apoptosis and might have clinical implications on acute myocardial infarction in future.

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Section: Discussionmentioning

confidence: 99%

Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes

Yang

Zhang

Liu

et al. 2013

ABBS

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“…Breast milk taurine content in rats ingesting the NTD was 0.21 + 0.01 pmol/ml defatted milk in contrast to a level of 0.12 + 0.01 pmol/ml in LTD fed and 1.26 + 0.06 pmol/ml in HTD fed animals. The level of taurine in milk is not influenced by the length of lactation, being similar in dams nursing 7-, 14-, or 21-day-old pups (17). These results indicate that the dietary exposure of nursing pups to taurine in the milk they are ingesting varies widely and is not dissimilar to the levels found in plasma and urine of older animals (5).…”

Section: Discussionmentioning

confidence: 66%

“…Alternately the filtered load of taurine, not measured in the present study, may vary suficiently to change tubular reabsorptions of taurine. Our previous study (17) indicates that plasma taurine values are significantly lower in LTD-nursed animals and thus the filtered load may be reduced. Renal cortex values of taurine are also lower in LTD-nursed pups (17), a finding in keeping with the hypothesis that cortex taurine pool size governs reabsorption and the renal adaptive response (10).…”

Section: Discussionmentioning

confidence: 90%

“…This study examines the age-related characteristics of taurine transport into vesicles isolated from nursing rats of three different ages-7, 14, and 21 days-and examines the influence of dietary sulfur amino acid alteration on intravesicular uptake. We have recently shown that breast milk taurine content varies in accordance with the amount of taurine or one of its precursors present in the diet fed the lactating dam (17). Breast milk taurine content in rats ingesting the NTD was 0.21 + 0.01 pmol/ml defatted milk in contrast to a level of 0.12 + 0.01 pmol/ml in LTD fed and 1.26 + 0.06 pmol/ml in HTD fed animals.…”

Section: Discussionmentioning

confidence: 96%

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Development Aspects of Renal β-Amino Acid Transport. V Brush Border Membrane Transport in Nursing Animals—Effect of Age and Diet

et al. 1986

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ABSTRACT. This study examines the Na+-dependent accumulation of the &amino acid, taurine, by brush border membrane vesicles isolated from nursing animals compared to uptake in adult animals. The diets fed to the mothers nursing these pups were altered so as to provide a low sulfur amino acid intake or a high taurine diet as well as conventional sulfur amino acid intake. Taurinuria is greater in nursing animals than in adult controls, but animals of all ages respond to exposure to the low sulfur amino acid intake by conservation of taurine and to the high taurine diet by hyperexcretion of taurine. Taurine uptake at 10 pM by brush border membrane vesicles is influenced by age in all groups and by diet in 14-and 21-day-old animals. A precession of uptake is seen both in terms of initial and peak rate of uptake with the lowest values in 7-day-old animals to the highest in adult. Greater brush border membrane vesicle uptake is found in 14-and 21-day-old rats after exposure to the low sulfur amino acid intake and reduced uptake after the HTD, whereas no dietary influence on uptake was found in 7-day-old rats. Neither the pattern of the time course of uptake nor the uptake values at equilibrium (45 min) are affected by age or diet. Kinetic analyses of concentration dependent uptake show that the maturational process involves a change in the Vmax of initial uptake. Kinetic analysis of the adaptive response reveals an increase in Vmax after low sulfur amino acid intake and a decline after high taurine diet in 14-and 21-day-old pups, but not in 7-day-old pups. Uptakes at high taurine concentrations (5 mM) which are 10-fold higher than the Km are uninfluenced by age or diet. This study indicates that the physiologic taurinuria of immature rats may relate, in part, to a lower rate of uptake at the brush border surface, but that after 1 wk and before 2 wk of age the kidney can adapt to changes in sulfur amino acid intake. (Pediatr Res 202390-894,1986 The renal tubular epithelium is involved in the reabsorption of various ions and nutrients, including amino acids that arise by virtue of filtration across the glomerular basement membrane. A "physiologic" aminoaciduria is evident in the young of all mammalian species. On the surface, aminoaciduria seems inappropriate in view of the need for a young, rapidly growing animal to conserve compounds that are important in growth (I, 2). Our lab has been concerned with those factors that contribute to the development of amino acid transport processes in the maturing animal and we hope to understand more fully whether maturation of the transport process can be accelerated by various physiologic manipulations (3-7). We have used as a transport probe, the p-amino acid, taurine, since one can manipulate the dietary intake of sulfur amino acids which results in a renal adaptive response for taurine (5,(8)(9)(10)(11)(12)(13).Full grown rats fed a limited sulfur amino acid intake reduce their urinary taurine excretion, a finding which is paralleled in vitro by augmented uptake of taurine by c...

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“…A concentração intracelular de taurina é de 5-50mM, a concentração plasmática de 40-100µM e no miocárdio é de, aproximadamente, 30mM, sendo que concentração plasmática ≤ 25µM é indicativo de depleção 14,29 . A taurina, também, protege o coração pela sua ação antiinflamatória, este aminoácido se liga ao ácido hiplocloroso (HOCl), poderoso oxidante, para formar a taurina cloramina (TauCl), composto mais estável.…”

Section: Dicadores Biológicosunclassified

Influência da deficiência de taurina no coração

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Studies on Renal Adaptation to Altered Dietary Amino Acid Intake: Tissue Taurine Responses in Nursing and Adult Rats

Cited by 39 publications

References 23 publications

Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes

Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes

Development Aspects of Renal β-Amino Acid Transport. V Brush Border Membrane Transport in Nursing Animals—Effect of Age and Diet

Influência da deficiência de taurina no coração

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