Studies on Regenarating Adrenal Cortex 1

Ichii, Shogo; Yago, Nagasumi; Kobayashi, Shigeru; Omata, Saburo

doi:10.1507/endocrj1954.15.271

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…Large mitochondria with vesicular cristae appeared after 20 days, when the plasma corticosterone concentration was over the control. However, some mitochondrial enzyme activity, necessary for the biosynthesis of corticosterone, was retained only a half of control level (Ichii et al, 1968). The fact that the vesicular cristae of some mitochondria were in a few number was compatible with the above-mentioned biochemical data, because the biosynthetic enzymes are localized to the inner membrane of mitochondria (Yago and Ichii, 1969).…”

Section: Discussionmentioning

confidence: 66%

“…Conditions under which the experimental animals were maintained and the technique used for adrenal enucleation were the same as described in the previous report (Ichii et al, 1968 …”

Section: Animalsmentioning

confidence: 99%

“…In a previous work (Ichii et al, 1968), process of the rat adrenocortical regeneration after bilateral enucleation was analyzed biochemically by examining the rate of incorporation of labeled nucleic acid precursors, together with DNA and RNA determinations and it was concluded that adrenal enucleation induced a rapid cellular proliferation which was almost completed 20 days after operation. corticosterone and in adrenocortical components, especially enzymes, which are considered to be related to corticosterone biosynthesis, were also investigated during the course of…”

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confidence: 99%

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Studies on Regenerating Adrenal Cortex 2. Autoradiographic and Electron Microscopic Observations

Seki¹,

Sekiyama²,

Miyahara³

et al. 1969

Endocrinol Japon

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Section: Discussionmentioning

confidence: 66%

“…Conditions under which the experimental animals were maintained and the technique used for adrenal enucleation were the same as described in the previous report (Ichii et al, 1968 …”

Section: Animalsmentioning

confidence: 99%

mentioning

confidence: 99%

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Studies on Regenerating Adrenal Cortex 2. Autoradiographic and Electron Microscopic Observations

Seki¹,

Sekiyama²,

Miyahara³

et al. 1969

Endocrinol Japon

Self Cite

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Sex differences in adrenocortical structure and function. XI

Malendowicz¹,

Jachimowicz²

1982

Cell Tissue Res.

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Adrenal glands from orchectomized and ovariectomized rats, with and without replacement therapy, and also from intact controls of both sexes, were examined by autoradiography with 3H-thymidine. The labelling index after 1 or 2 nucleoside injections was higher in the zona glomerulosa of females than in male rats, while no differences were found in the fascicular and reticular zones. Orchiectomy increased the labelling index in the fascicular and reticular zones, an effect prevented by testosterone. Ovariectomy did not change the labelling index, while estradiol lowered it in the zona glomerulosa. Duration of the S phase was longer in the zona fasciculata cells of males than in females. Both orchiectomy and testosterone shortened this phase in cells of the zona fasciculata and zona reticularis. Ovariectomy prolonged the S phase in the zona fasciculata and shortened this time in the reticular zone, an effect reversed by estradiol. In the glomerular and fascicular zones, cell cycle time was longer in males than in females. Orchiectomy shortened this time in all adrenocortical zones, an effect reversed by testosterone. Ovariectomy shortened cell cycle time in the glomerular and reticular zones and prolonged it in the zona fasciculata; these effects were reversed by estradiol. Turnover rate in adrenocortical cells was markedly higher in females than in males, a difference due to testosterone which markedly decreased turnover rate.

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