Studies on Pyrazines. Part 39. Synthesis and Acidic Hydrolysis of 2‐Hydroxy‐5‐methoxypyrazine.

Sato, Nobuhiro; Mizuno, Akio

doi:10.1002/chin.200615155

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“…In addition, some previous publications have reported the melting point but no fusion enthalpy of C 4 H 3 BrN 2 O. 21 The T m of C 4 H 3 BrN 2 O obtained in this work was greater than the value in ref 21 (388.15−389.15 K). The small difference was acceptable and may be caused by the difference in accuracy of the equipment, purity of the sample, or test methods.…”

Section: ■ Introductionmentioning

confidence: 99%

Solubility and Data Correlation of 2-Bromo-5-hydroxypyrazine in Four Cosolvent Mixtures and Ten Mono-Solvents from 278.15 to 323.15 K

2023

J. Chem. Eng. Data

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The experimental solubility of 2-bromo-5-hydroxypyrazine dissolved in 10 mono-solvents (methanol, ethanol, isopropanol, N,N-dimethylformamide (DMF), npropanol, acetonitrile, acetone, ethylene glycol (EG), propylene glycol (PG), water) and cosolvent mixtures of methanol + water, ethanol + water, isopropanol + water, and DMF + water was determined by the isothermal saturation method between 278.15 and 323.15 K at 101.2 kPa. The largest solubility was observed in DMF + 2-bromo-5hydroxypyrazine for mono-solvent systems and in DMF + water for mixed solvent systems. The Jouyban−Acree model (J−A), van't Hoff−Jouyban−Acree model (V−J− A), and Apelblat−Jouyban−Acree model (A−J−A) were utilized to correlate the 2bromo-5-hydroxypyrazine solubility in mixtures, and the Apelblat model, van't Hoff model, λh model, and Jouyban model were used to correlate the 2-bromo-5hydroxypyrazine solubility in 10 mono-solvents. The preferential solvation of 2bromo-5-hydroxypyrazine in mixed solvents was researched by calculation of δx 1,3 . This study presents insights into modulating the 2-bromo-5-hydroxypyrazine crystallization process and in understanding equilibrium behaviors in different solvents.

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Section: ■ Introductionmentioning

confidence: 99%

Solubility and Data Correlation of 2-Bromo-5-hydroxypyrazine in Four Cosolvent Mixtures and Ten Mono-Solvents from 278.15 to 323.15 K

2023

J. Chem. Eng. Data

View full text Add to dashboard Cite

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Studies on Pyrazines. Part 39. Synthesis and Acidic Hydrolysis of 2‐Hydroxy‐5‐methoxypyrazine.

Cited by 1 publication

References 1 publication

Solubility and Data Correlation of 2-Bromo-5-hydroxypyrazine in Four Cosolvent Mixtures and Ten Mono-Solvents from 278.15 to 323.15 K

Solubility and Data Correlation of 2-Bromo-5-hydroxypyrazine in Four Cosolvent Mixtures and Ten Mono-Solvents from 278.15 to 323.15 K

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