Studies on prolactin-secreting cells in aging rats of different strains. I. Alterations in pituitary histology and serum prolactin levels as related to aging

Putten, L.J.A. van; Zwieten, Matthew J. van; Mattheij, J.A.M.; Kemenade, J. A. M. van

doi:10.1016/0047-6374(88)90064-4

Cited by 23 publications

(7 citation statements)

References 17 publications

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“…The most common cause of death in old SD rats in general and in SD rats in this study was pituitary tumors in both sexes and mammary gland tumors in females (3,20,22,23,44,50,68). At 52 wk, the 5002 AL and 5002-9 AL rats of both sexes and the 5002 DR 6.5 hr females had the largest pituitaries and the highest incidence of pituitary adenomas or focal hyperplasias.…”

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confidence: 48%

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The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging

et al. 1994

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A significant correlation exists between average daily food consumption and 2-yr survival in control ad libitum (AL)-fed Sprague-Dawley (SD) rats. SD rats were fed Punna Rodent Chow 5002 or a modified chow, 5002-9, with lower protein, fat, metabolizable energy and increased fiber AL or by dietary restriction (DR) to 65% of the AL amount by measurement or time (6.5 hr). At 52 wk, food consumption and key pathology biomarkers correlated with 106-wk survival. The modified chow, 5002-9 fed AL, did not significantly improve survival. SD rats fed either diet A,L consumed the greatest amount of feed and kcallrat but consumed the same amount of feed per gram body weight as DR-fed rats. At 52 wk, AL rats fed either diet had the same brain weights as D R rats, but the AL-fed rats had greater body weight and body fat content and increased heart, lung, kidney, liver, adrenal, thyroid, and pituitary weights as well as an increased incidence and seventy of degenerative and/or proliferative lesions in these organs. This study demonstrates that overfeeding best correlates with low 2-yr survival in SD rats and that simple DR by caloric restriction modifies key pathology biomarkers in the pituitary, mammary gland, kidney, and heart of SD rats at 52 wk that are predictive of 106-wk survival.

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confidence: 48%

“…Since increased prolactin secretion has been associated with pituitary adenomas (46,61,62,67,68), it is not surprising that the 5002 AL and 5002-9 AL females had the only mammary gland fibroadenomas at 52 wk. The 5002 AL females also had the highest incidence of galactoceles at this time.…”

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confidence: 99%

The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging

et al. 1994

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“…Diffuse atrophy of a pituitary cell population also occurs in association with hyperplasia of other cell types (see below) or focally around the margins of expanding pituitary neoplasms. 30 When rats are exposed to low barometric pressure for 28 days, the number of thyrotrophs decreases to about 30% of controls without significant cytological changes or hypertrophy. Quantitative immunocytochemical study has shown that these age-related changes are mainly due to a decline both in the number and size of growth hormone-producing cells, the greatest decline occurring at about the age of 40.…”

Section: Atrophy and Hypoplasiamentioning

confidence: 99%

Endocrine Glands

Greaves¹

2012

Histopathology of Preclinical Toxicity Studies

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“…Prolactin (PRL) containing adenomas are the most common, followed by luteinizing hormone (LH) adenomas and immunonegative adenomas; mixed PRL-growth hormone (GH) adenomas also have been described (44). The development of PRL-secreting pituitary tumors in aging animals generally correlates with increased PRL serum levels (66,67).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats

et al. 2003

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This study compared the effects of ad libitum (AL) overfeeding and moderate or marked dietary restriction (DR) on the pathogenesis of aged-related pituitary gland changes in Sprague-Dawley (SD) rats. SD rats were fed Purina Certified Rodent Diet AL (group 1), DR at 72-79% of AL (group 2), DR at 68-72% of AL (group 3) or DR at 47-48% of AL (group 4) for 106 weeks. Interim necropsies were performed at 13, 26, and 53 weeks, after a 7-day 5-bromo-2-deoxyuridine (BrdU)-filled minipump implantation. Body weights, organ weights and insulin-like growth factor 1 (IGF-1) serum levels were measured at interim and final necropsies. Serum levels of prolactin (PRL), progesterone, estradiol, luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured at 53 and/or 106 weeks. In addition to the routine histopathologic examination, determination of 7 stereologic parameters after pituitary immunohistochemistry of PRL, growth hormone (GH) and BrdU was done in both sexes at 13, 26, and 53 weeks. Body and pituitary weights were proportional to the food intake. In AL-fed rats, hyperplastic and neoplastic changes developed early and progressed with age, affecting almost all animals by 106 weeks. These changes were associated with high PRL serum levels. Pituitary adenomas were the most common cause of death in both sexes. In DR rats, a delayed onset and a decreased incidence of pituitary tumors were observed in association with decreased serum IGF-1, PRL, estradiol, and LH levels. The results of the stereological analysis demonstrated that, compared to AL-fed rats, pituitary glands from DR rats contained lower PRL and GH secreting cell volumes, and a lower epithelial cell BrdU labeling index, which correlated with a lower incidence of pituitary tumors at study termination. Moderate and marked degrees of DR delayed the onset of pituitary tumors in a temporal- and dose-related manner. In contrast to marked DR, which dramatically reduced the incidence of hyperplastic and neoplastic pituitary gland changes, moderate DR delayed the onset but did not prevent the development of pituitary tumors.

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Studies on prolactin-secreting cells in aging rats of different strains. I. Alterations in pituitary histology and serum prolactin levels as related to aging

Cited by 23 publications

References 17 publications

The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging

The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging

Endocrine Glands

The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague—Dawley Rats

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