Studies on ovine efferent lymph following infection with Toxoplasma gondii

McColgan, Christina; Buxton, D.; Miller, H. R. P.

doi:10.1016/0021-9975(87)90081-8

Cited by 8 publications

(2 citation statements)

References 24 publications

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“…In our study the oral inoculation with tissue cysts resulted in a more rapid antibody response. However, this response was similar to the one observed by McColgan et al [ 54 ], which saw IgG appear nine days after experimental infection with tissue cysts [ 54 ]. This again supports the hypothesis that the parasite passes the intestinal epithelial barrier more quickly after an oral infection with tissue cysts, although it can not be excluded that the earlier response was a result of strain differences [ 8 , 14 , 55 ].…”

Section: Discussionsupporting

confidence: 90%

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Parasite distribution and associated immune response during the acute phase of Toxoplasma gondiiinfection in sheep

Verhelst

Craeye

Entrican³

et al. 2014

BMC Vet Res

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BackgroundIn many countries, Toxoplasma gondii (T. gondii) is a major cause of reproductive disorders and abortions in the sheep industry, and therefore responsible for important financial and economic losses. In addition, undercooked infected lamb is an important risk factor for human toxoplasmosis.In the present study, the initial phase of the infection was investigated: the parasite’s entry site, the subsequent distribution of the parasite and the host-immune response.ResultsParasite DNA was already detected in the cranial small intestinal mucosa the first days after oral infection with T. gondii tissue cysts. Simultaneously, high IFN-gamma and IL-12 responses were induced mainly in the mesenteric lymph nodes. The emergence of IgG1 (at 8dpi), and IgG2 (at 11 dpi) was accompanied by a decrease or even disappearance of the IFN-gamma and IL-12 response in the Peyers’ patches (PP), PBMC’s and popliteal LN’s. Meanwhile the parasite DNA could be recovered from most mucosal and systemic tissues to become undetectable in the small intestine, popliteal LN, PBMC and spleen 3 weeks pi.ConclusionsOur results indicate that parasites enter the cranial small intestine the first days after infection and that after an increase the first two weeks after infection, the parasite DNA levels in the intestine drop below the detection limit three weeks after infection. This coincides with an increase in parastic-specific serum IgG1 and IgG2 and a decrease of the antigen-specific IFN-gamma response in PP, PBMC and popliteal LN. We suggest a role for IFN-gamma and IL-12 in controlling the infection.

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Section: Discussionsupporting

confidence: 90%

“…The latter is a non-natural infection. One other study analyzed the immune after a subcutaneous infection with tissue cysts, a non-natural infection route [ 54 ].…”

Section: Discussionmentioning

confidence: 99%