Studies on Organic Insecticides

KONISHI, Kazuo

doi:10.1271/bbb1961.34.926

Cited by 11 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nereistoxin insecticides are effective for lepidopteran, hemipteran and coleopteran pest control. Konishi synthesized and studied the insecticidal activity of many nereistoxin derivatives and established the structure-activity relationship (SAR) of nereistoxin derivatives [9][10][11][12]. However, there are only five insecticide products (Figure 1) currently Molecules 2023, 28, 4846 2 of 16 on the market that use nereistoxin as their active ingredient.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate

Yan¹,

Lu²,

Zhang³

et al. 2023

Molecules

View full text Add to dashboard Cite

Novel nereistoxin derivatives containing phosphonate were synthesized and characterized via 31P, 1H and 13C NMR and HRMS. The anticholinesterase activity of the synthesized compounds was evaluated on human acetylcholinesterase (AChE) using the in vitro Ellman method. Most of the compounds exhibited good inhibition of acetylcholinesterase. All of these compounds were selected to assess their insecticidal activity (in vivo) against Mythimna separata Walker, Myzus persicae Sulzer and Rhopalosiphum padi. Most of the tested compounds displayed potent insecticidal activity against these three species. Compound 7f displayed good activity against all three insect species, showing LC50 values of 136.86 μg/mL for M. separata, 138.37 μg/mL for M. persicae and 131.64 μg/mL for R. padi. Compound 7b had the highest activity against M. persicae and R. padi, with LC50 values of 42.93 μg/mL and 58.19 μg/mL, respectively. Docking studies were performed to speculate the possible binding sites of the compounds and explain the reasons for the activity of the compounds. The results showed that the compounds had lower binding energies with AChE than with the acetylcholine receptor (AchR), suggesting that compounds are more easily bound with AChE.

show abstract

Section: Introductionmentioning

confidence: 99%

“…(SAR) of nereistoxin derivatives [9][10][11][12]. However, there are only five insecticide products (Figure 1) currently on the market that use nereistoxin as their active ingredient.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate

Yan¹,

Lu²,

Zhang³

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…3.1.2.3 Synthesis of phosphorothioic acid, S,S 0 -[alkyl amino-1,3-propanediyl]O,O,O 0 O 0 -tetra ester (5)(6)(7)(8)(9). Novel synthesized compounds 5-9 were prepared by the reaction of 3 mmol (3 eq.)…”

Section: Molecular Dockingmentioning

confidence: 99%

“…These NTX analogs have demonstrated effective control over lepidopteran, hemipteran, and coleopteran pests. 8,9 Furthermore, they are considered safe for humans and domestic animals since they can be broken down and excreted. However, the long-term, repeated, and extensive use of these insecticides has inevitably led to the development of pesticide resistance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, biological evaluation and molecular docking of novel nereistoxin derivatives containing phosphonates as insecticidal/AChE inhibitory agents

Yan,

Lu,

Wang

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: ORGANISCHE INSEKTICIDE 11. MITT. SYNTH. VON NEREISTOXIN UND VERWANDTEN VERBINDUNGEN, (4. TEIL)

Konishi¹

1970

Chemischer Informationsdienst. Organische Chemie

View full text Add to dashboard Cite

2‐Dimethylamino‐1,3‐dichlorpropan (I) und 1‐Dimethylamino‐2,3‐dichlorpropan (III) reagieren mit Schwefelnucleophilen, wie Ammoniumhydrogensulfid, Thioharnstoff, Kaliumthiocyanat, Natriumthiosulfat usw., in einer intramolekularen SN2‐Reaktion in polaren organischen Lösungsmitteln über das Äthylenimmoniumion (II) als Zwischenstufe in unterschiedlichen Ausbeuten bevorzugt zu den Dihydronereistoxin‐Derivaten (IV) und zu den Thiolestern (V), wobei sich das Verhältnis von (IV) zu (V) durch Veränderung der Reaktionsbedingungen variieren läßt. Das Bunte‐Salz (IVk) setzt sich mit NaCN zu (IVj) und mit Natrium‐iso‐propyl‐ bzw. ‐p‐chlor‐phenyl‐ mercaptid zu (VI) um.

show abstract

Studies on Organic Insecticides

Abstract: Insecticidally active sulfur derivatives (VI) of dihydronereistoxin (VIa) were synthesized in one step sequence starting from 2-dimethylamino-l,3-dichloropropane (III) or 1-dimethylamino-2,3-dichloropropane (IV) by utilizing intramolecular SN 2 reaction.

Cited by 11 publications

References 0 publications

Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate

Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate

Synthesis, biological evaluation and molecular docking of novel nereistoxin derivatives containing phosphonates as insecticidal/AChE inhibitory agents

ChemInform Abstract: ORGANISCHE INSEKTICIDE 11. MITT. SYNTH. VON NEREISTOXIN UND VERWANDTEN VERBINDUNGEN, (4. TEIL)

Contact Info

Product

Resources

About