Studies on Oestrogen Metabolism in New-Born Boys

Diczfalusy, E.; Tillinger, K.‐G.; Westman, Anna

doi:10.1530/acta.0.0260313

Cited by 10 publications

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“…of distilled water (Brown partition lor the separation of oestriol from oestrone + oestradiol-17ß). From this stage the extracts were treated according to the method of Brown (1955), except for some slight modifications in the deactivation of alumina and in the composition of solvents, described previously (Diczfalusy 8c Westman. 1956).…”

Section: Collection Of Meconiummentioning

confidence: 99%

Studies on Oestrogen Metabolism in Newborn Boys

Diczfalusy¹,

Menini²,

Tillinger³

et al. 1959

Acta Endocrinologica

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The oestrogen excretion pattern of the urine of newborn boys is characterized by the presence of huge amounts of oestriol, which is accompanied by the virtual absence of oestrone and oestradiol-17\g=b\(Diczfalusy et al., 1957 a). Furthermore, whereas oestriol has been isolated in good yield from the human meconium, oestrone and oestradiol-17\g=b\ have so far not been isolated from this source (Kinsella et al., 1956). These findings suggested that a detailed investigation of the oestrogen pattern of the meconium might be of value.In the present paper a quantitative study of the faecal oestrogen excretion in newborn boys is reported. Data are presented indicating that huge amounts of oestriol are excreted by this route during the first few days of life and that oestriol is the principal, or perhaps the only Kober chromogen present in meconium. EXPERIMENTAL Collection of meconiumFor the collection of meconium, the usual anaesthetic masks were adapted to the anus. Urine was collected at the same time with a special glass container fitted to the penis. In this way any contamination of the meconium by urine was avoided. Collections were made daily from the 2nd to 6th day of life. Meconium from the same period was pooled from at least three boys. Following the collection and prior to analysis, the samples were kept in a refrigerator at -5°. Extraction was invariably carried out within a week from the start of collection.

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Section: Collection Of Meconiummentioning

confidence: 99%