Studies on neutralization of japanese encephalitis virus (JEV)

Iwasaki, Taku; Ogura, R

doi:10.1016/0042-6822(68)90017-2

Cited by 13 publications

(2 citation statements)

References 17 publications

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“…The divergence from linearity in the neutralization curves with monoclonal antibodies is characteristic for viral neutralization curves reported by a large number of investigators using conventional antiserum (10,14,16,17,26). This divergence has been attributed to antibody heterogeneity in which nonneutralizing or poorly bound antibodies compete with neutralizing antibodies.…”

Section: Resultsmentioning

confidence: 93%

Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

Volk¹,

Synder²,

Benjamin³

et al. 1982

J Virol

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Nineteen independently isolated hybridomas producing monoclonal antibodies to the glycoprotein of vesicular stomatitis virus were isolated and studied for their capacity to neutralize viral infectivity. By measuring competitive binding of 125ilabeled monoclonal antibodies in a radioimmunoassay, 11 different, non-crossreacting antigenic determinants were identified on the vesicular stomatitis virus G protein. All monoclonal antibodies reacting with determinants 1, 2, 3, and 4 resulted in viral neutralization, whereas those binding to the other seven determinants did not neutralize infectivity. A mixture of two monoclonal antibodies binding to different determinants resulted in a more rapid neutralization than either antibody alone, suggesting that different antibodies can exert a synergistic effect on viral neutralization. Kinetic experiments revealed biphasic neutralization curves similar to those expected for heterologous antibody. No evidence could be obtained to relate biphasic kinetics of viral neutralization to heterogeneous populations either of antibody molecules or of virus. The possible significance of the kinetic data with monoclonal antibodies is discussed.

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Section: Resultsmentioning

confidence: 93%

Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

Volk¹,

Synder²,

Benjamin³

et al. 1982

J Virol

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“…Humoral immunity driven by B cells with Th2 cell leads to the inhibition of viral replication and spread in the initial stages. For example, virus neutralizing antibody-mediated inhibition of JEV replication leads to the inhibition of the cytopathic effects of the virus and hence less tissue damage in Japanese encephalitis (68). CD4 + Th2 cells may provide a protective role against viral encephalitis during infection with neurotrophic virus.…”

Section: The Role Of Cd4+ Th Subsets In Acute Viral Encephalitismentioning

confidence: 99%

The Roles and Perspectives of Toll-Like Receptors and CD4⁺Helper T Cell Subsets in Acute Viral Encephalitis

Han

Singh

2012

Immune Netw

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Acute viral encephalitis caused by neurotrophic viruses, such as mosquito-borne flaviviruses, is an emerging and re-emerging disease that represents an immense global health problem. Considerable progression has been made in understanding the pathogenesis of acute viral encephalitis, but the immune-pathological processes occurring during the progression of encephalitis and the roles played by various molecules and cellular components of the innate and adaptive systems still remain undefined. Recent findings reveal the significant contribution of Toll-like receptors (TLRs) and regulatory CD4+ T cells in the outcomes of infectious diseases caused by neurotrophic viruses. In this review, we discuss the ample evidence focused on the roles of TLRs and CD4+ helper T cell subsets on the progression of acute viral encephalitis. Finally, we draw attention to the importance of these molecules and cellular components in defining the pathogenesis of acute viral encephalitis, thereby providing new therapeutic avenues for this disease.

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Interaction of Viruses with Neutralizing Antibodies

Mandel

1979

Comprehensive Virology

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Studies on neutralization of japanese encephalitis virus (JEV)

Cited by 13 publications

References 17 publications

Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

The Roles and Perspectives of Toll-Like Receptors and CD4⁺Helper T Cell Subsets in Acute Viral Encephalitis

Interaction of Viruses with Neutralizing Antibodies

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Studies on neutralization of japanese encephalitis virus (JEV)

Cited by 13 publications

References 17 publications

Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

Monoclonal antibodies to the glycoprotein of vesicular stomatitis virus: comparative neutralizing activity

The Roles and Perspectives of Toll-Like Receptors and CD4+Helper T Cell Subsets in Acute Viral Encephalitis

Interaction of Viruses with Neutralizing Antibodies

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Product

Resources

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The Roles and Perspectives of Toll-Like Receptors and CD4⁺Helper T Cell Subsets in Acute Viral Encephalitis