Studies on metal complexes of 2-((8-hydroxyquinolin-5-yl)methylene)benzo[b]thiophen-3(2H)-one 1,1-dioxide

Patel, Yogesh

doi:10.1007/s11164-014-1764-9

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…6, 2 A basic component of organic light emitting diode (OLEDs) is Alq3 which is produced by the reaction of 1-azanapthalene and aluminum (III). 4 8-HQ and its derivatives have multiple applications that range from pharmacological and pharmaceutical agents to carries the electron in OLEDs and fluorescent chemo sensor for metal ions as well as very useful chelating agent in analytical and radioactive chemistry.…”

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Khalid¹,

Ali²,

Aslam³

et al. 2017

IJPSR

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N-heterocyclic compounds have extensive biological and pharmaceutical applications. 8-Hydroxyquinoline (8-HQ) also plays a significant role in many fields of life. The excellent biological significance of the 8-HQ prompted us to extend the DFT based studies. The frontier molecular orbitals (FMOs), UV-VIS and solvation model based studies remained unknown. Therefore, we intended to study the natural bond orbital, FMOs, UV-VIS, thermodynamic properties and medium influence on solvation energies, dipole moment, FT-IR and FT-Raman using polarizable continuum model (PCM) and density-based solvation model (SMD). The electronic properties of molecule were calculated by M06-2X/6-31G (d,P) and B3LYP/6-31G (d,p) level of theories. The solvent influence on the geometric parameters, FT-IR and FT-Raman were studied by B3LYP /6-31G(d) method. A good correspondence is found between the optimized parameters and the reported X-ray data. Natural bond orbital reveals that the maximum stabilization energy reached up to 39.64kJ/mol which is responsible for extra stability of the molecule. In solvated 8-HQ, a significant medium effects on FT-IR and FT-Raman intensities is observed. The intensities enhanced from gas to solvent phase. The solvation free energies are found to be -28.710 and -39.456 kJ/mol in PCM and SMD models respectively. FMOs suggested that this molecule contain less hardness and larger softness values. These findings reveal that the molecule might be bioactive.

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confidence: 99%

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Khalid¹,

Ali²,

Aslam³

et al. 2017

IJPSR

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“…Various approaches can be visualized to synthesize or modify metal complex structures by utilizing the reactivity of this heterocycle with various derivatives [1][2][3][4][5][6][7][8][9][10][11][12]. 8HQ and its derivatives are also showing the bioactivities, including anticancer [13,14], antibacterial [15,16], antidyslipidemic and antioxidative properties [17], vasorelaxing properties [18], antivirus [19,20], and antiplatelet [21] activities.…”

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confidence: 99%

Studies on metal complexes of 1-((8-hydroxyquinolin-5-yl)methyl)-3-(thiazol-2-ylimino)indolin-2-one

Patel

2015

Res Chem Intermed

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Novel ligand 1-((8-hydroxyquinolin-5-yl)methyl)-3-(thiazol-2-ylimino)indolin-2-one was synthesized by condensation of 5-(chloromethyl)-1,8a-dihydroquinolin-8-ol with 3-(thiazol-2-ylimino)indolin-2-one. Metal complexes of this ligand were prepared using various transition metal ion salts, viz., Mn(II), Fe(II), Co(II), Ni(II), Cu(II), and Zn(II). All synthesized compounds were characterized by various spectroscopic techniques. Thermogravimetric analysis of metal complexes was also carried out. Geometry of the metal complexes was carried out by electronic spectral analysis and magnetic measurement studies. The ligand and metal complexes were screened for their antibacterial activities against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa. The metal complexes are found more potent bactericides than the ligand. The interaction of ligand and its complexes with plasmid (pUC 19) DNA and calf thymus DNA was investigated by gel electrophoresis measurements. The superoxide dismutase mimetic activity of the ligand and its metal complexes has also been assessed for their ability to inhibit the reduction of nitrobluetetrazolium chloride.

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